Soft-Tissue Infections of Ampicillin-Resistant Haemophilus influenzae Type b: The Use of Ampicillin and Nafcillin in Their Treatment

The combination of intravenous ampicillin sodium and nafcillin sodium followed by oral ampicillin and dicloxacillin sodium was effective in treating five infants with soft-tissue infections and bacteremia due to β-lactamase—producing, ampicillin-resistant Haemophilus influenzae type b. This antibiotic combination seems to be an effective alternative to chloramphenicol for treatment of nonmeningitic invasive disease due to moderately ampicillin-resistantH influenzae type b. The use of this combination should be in conjunction with appropriate in vitro tests whose results demonstrate synergism.