Soft Wearable Systems for Colorimetric and Electrochemical Analysis of Biofluids

Roozbeh Ghaffari*, Jungil Choi, Milan S. Raj, Shulin Chen, Stephen P. Lee, Jonathan T. Reeder, Alexander J. Aranyosi, Adam Leech, Weihua Li, Stephanie Schon, Jeffrey B. Model, John A. Rogers

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

54 Scopus citations


Wearable monitoring systems provide valuable insights about the state of wellness, performance, and progression of diseases. Although conventional wearable systems have been effective in measuring a few key biophysical markers, they offer limited insights into biochemical activity and are otherwise cumbersome in ambulatory modes of use, relying on wired connections, mechanical straps, and bulky electronics. Recent advances in skin-interfaced microfluidics, stretchable/flexible electronics, and mechanics have created new wearable systems with capabilities in real-time, noninvasive analysis of sweat biochemistry in combination with biophysical metrics. Here, the latest technologies in multifunctional sweat sensing systems are presented with a focus on novel microfluidic designs, fully-integrated wireless electrochemical sensors, and hybrid biochemical/biophysical sensing capabilities, creating real-time physiological insights.

Original languageEnglish (US)
Article number1907269
JournalAdvanced Functional Materials
Issue number37
StatePublished - Sep 1 2020


  • bioassays
  • bioelectronics
  • electrochemistry
  • microfluidics
  • personalized medicine

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics


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