Soft Wearable Systems for Colorimetric and Electrochemical Analysis of Biofluids

Roozbeh Ghaffari; Jungil Choi; Milan S. Raj; Shulin Chen; Stephen P. Lee; Jonathan T. Reeder; Alexander J. Aranyosi; Adam Leech; Weihua Li; Stephanie Schon; Jeffrey B. Model; John A. Rogers

doi:10.1002/adfm.201907269

Soft Wearable Systems for Colorimetric and Electrochemical Analysis of Biofluids

Roozbeh Ghaffari^*, Jungil Choi, Milan S. Raj, Shulin Chen, Stephen P. Lee, Jonathan T. Reeder, Alexander J. Aranyosi, Adam Leech, Weihua Li, Stephanie Schon, Jeffrey B. Model, John A. Rogers

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

54 Scopus citations

Abstract

Wearable monitoring systems provide valuable insights about the state of wellness, performance, and progression of diseases. Although conventional wearable systems have been effective in measuring a few key biophysical markers, they offer limited insights into biochemical activity and are otherwise cumbersome in ambulatory modes of use, relying on wired connections, mechanical straps, and bulky electronics. Recent advances in skin-interfaced microfluidics, stretchable/flexible electronics, and mechanics have created new wearable systems with capabilities in real-time, noninvasive analysis of sweat biochemistry in combination with biophysical metrics. Here, the latest technologies in multifunctional sweat sensing systems are presented with a focus on novel microfluidic designs, fully-integrated wireless electrochemical sensors, and hybrid biochemical/biophysical sensing capabilities, creating real-time physiological insights.

Original language	English (US)
Article number	1907269
Journal	Advanced Functional Materials
Volume	30
Issue number	37
DOIs	https://doi.org/10.1002/adfm.201907269
State	Published - Sep 1 2020

Keywords

bioassays
bioelectronics
electrochemistry
microfluidics
personalized medicine

ASJC Scopus subject areas

Chemistry(all)
Materials Science(all)
Condensed Matter Physics

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10.1002/adfm.201907269

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title = "Soft Wearable Systems for Colorimetric and Electrochemical Analysis of Biofluids",

abstract = "Wearable monitoring systems provide valuable insights about the state of wellness, performance, and progression of diseases. Although conventional wearable systems have been effective in measuring a few key biophysical markers, they offer limited insights into biochemical activity and are otherwise cumbersome in ambulatory modes of use, relying on wired connections, mechanical straps, and bulky electronics. Recent advances in skin-interfaced microfluidics, stretchable/flexible electronics, and mechanics have created new wearable systems with capabilities in real-time, noninvasive analysis of sweat biochemistry in combination with biophysical metrics. Here, the latest technologies in multifunctional sweat sensing systems are presented with a focus on novel microfluidic designs, fully-integrated wireless electrochemical sensors, and hybrid biochemical/biophysical sensing capabilities, creating real-time physiological insights.",

keywords = "bioassays, bioelectronics, electrochemistry, microfluidics, personalized medicine",

author = "Roozbeh Ghaffari and Jungil Choi and Raj, {Milan S.} and Shulin Chen and Lee, {Stephen P.} and Reeder, {Jonathan T.} and Aranyosi, {Alexander J.} and Adam Leech and Weihua Li and Stephanie Schon and Model, {Jeffrey B.} and Rogers, {John A.}",

note = "Funding Information: R.G. and J.C. contributed equally to this work. This research was supported by the Northwestern University Center for Bio-Integrated Electronics and the Simpson Querrey Institute for BioNanotechnology. This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government. (MSIT) (NRF-2019R1A2C1084419). Publisher Copyright: {\textcopyright} 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim",

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month = sep,

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doi = "10.1002/adfm.201907269",

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volume = "30",

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AU - Chen, Shulin

AU - Lee, Stephen P.

AU - Reeder, Jonathan T.

AU - Aranyosi, Alexander J.

AU - Leech, Adam

AU - Li, Weihua

AU - Schon, Stephanie

AU - Model, Jeffrey B.

AU - Rogers, John A.

N1 - Funding Information: R.G. and J.C. contributed equally to this work. This research was supported by the Northwestern University Center for Bio-Integrated Electronics and the Simpson Querrey Institute for BioNanotechnology. This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government. (MSIT) (NRF-2019R1A2C1084419). Publisher Copyright: © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

PY - 2020/9/1

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N2 - Wearable monitoring systems provide valuable insights about the state of wellness, performance, and progression of diseases. Although conventional wearable systems have been effective in measuring a few key biophysical markers, they offer limited insights into biochemical activity and are otherwise cumbersome in ambulatory modes of use, relying on wired connections, mechanical straps, and bulky electronics. Recent advances in skin-interfaced microfluidics, stretchable/flexible electronics, and mechanics have created new wearable systems with capabilities in real-time, noninvasive analysis of sweat biochemistry in combination with biophysical metrics. Here, the latest technologies in multifunctional sweat sensing systems are presented with a focus on novel microfluidic designs, fully-integrated wireless electrochemical sensors, and hybrid biochemical/biophysical sensing capabilities, creating real-time physiological insights.

AB - Wearable monitoring systems provide valuable insights about the state of wellness, performance, and progression of diseases. Although conventional wearable systems have been effective in measuring a few key biophysical markers, they offer limited insights into biochemical activity and are otherwise cumbersome in ambulatory modes of use, relying on wired connections, mechanical straps, and bulky electronics. Recent advances in skin-interfaced microfluidics, stretchable/flexible electronics, and mechanics have created new wearable systems with capabilities in real-time, noninvasive analysis of sweat biochemistry in combination with biophysical metrics. Here, the latest technologies in multifunctional sweat sensing systems are presented with a focus on novel microfluidic designs, fully-integrated wireless electrochemical sensors, and hybrid biochemical/biophysical sensing capabilities, creating real-time physiological insights.

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Soft Wearable Systems for Colorimetric and Electrochemical Analysis of Biofluids

Abstract

Keywords

ASJC Scopus subject areas

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