Solid-phase syntheses of N(ω)-propylarginine-containing dipeptides, dipeptide esters, and dipeptide amides

Younghee Lee, Richard B Silverman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

An efficient method for the solid-phase synthesis of N(ω)propylarginine-containing dipeptide analogues is presented. A variety of polymer-bound dipeptide analogues with L-ornithine at the Nor C-terminus was formed on the solid support, and the conversion of polymer-bound ornithine to N(ω)-propylarginine generated the desired dipeptides. 1H-Pyrazole-N-propyl- 1-carboxamidine was found to be an effective guanylating agent.

Original languageEnglish (US)
Pages (from-to)1495-1499
Number of pages5
JournalSynthesis
Issue numberSPEC. ISS.
StatePublished - Jan 1 1999

Keywords

  • Guanylating agent
  • Propylarginine-containing dipeptides
  • Solid-phase synthesis

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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