Solid-phase syntheses of N(ω)-propylarginine-containing dipeptides, dipeptide esters, and dipeptide amides

Younghee Lee; Richard B. Silverman

doi:10.1055/s-1999-6077

Solid-phase syntheses of N(ω)-propylarginine-containing dipeptides, dipeptide esters, and dipeptide amides

Younghee Lee, Richard B. Silverman^*

^*Corresponding author for this work

Robert H. Lurie Comprehensive Cancer Center

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

An efficient method for the solid-phase synthesis of N(ω)propylarginine-containing dipeptide analogues is presented. A variety of polymer-bound dipeptide analogues with L-ornithine at the Nor C-terminus was formed on the solid support, and the conversion of polymer-bound ornithine to N(ω)-propylarginine generated the desired dipeptides. 1H-Pyrazole-N-propyl- 1-carboxamidine was found to be an effective guanylating agent.

Original language	English (US)
Pages (from-to)	1495-1499
Number of pages	5
Journal	Synthesis
Issue number	SPEC. ISS.
DOIs	https://doi.org/10.1055/s-1999-6077
State	Published - 1999

Keywords

Guanylating agent
Propylarginine-containing dipeptides
Solid-phase synthesis

ASJC Scopus subject areas

Catalysis
Organic Chemistry

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10.1055/s-1999-6077

Cite this

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abstract = "An efficient method for the solid-phase synthesis of N(ω)propylarginine-containing dipeptide analogues is presented. A variety of polymer-bound dipeptide analogues with L-ornithine at the Nor C-terminus was formed on the solid support, and the conversion of polymer-bound ornithine to N(ω)-propylarginine generated the desired dipeptides. 1H-Pyrazole-N-propyl- 1-carboxamidine was found to be an effective guanylating agent.",

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author = "Younghee Lee and Silverman, {Richard B.}",

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language = "English (US)",

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journal = "Synthesis",

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T1 - Solid-phase syntheses of N(ω)-propylarginine-containing dipeptides, dipeptide esters, and dipeptide amides

AU - Lee, Younghee

AU - Silverman, Richard B.

PY - 1999

Y1 - 1999

N2 - An efficient method for the solid-phase synthesis of N(ω)propylarginine-containing dipeptide analogues is presented. A variety of polymer-bound dipeptide analogues with L-ornithine at the Nor C-terminus was formed on the solid support, and the conversion of polymer-bound ornithine to N(ω)-propylarginine generated the desired dipeptides. 1H-Pyrazole-N-propyl- 1-carboxamidine was found to be an effective guanylating agent.

AB - An efficient method for the solid-phase synthesis of N(ω)propylarginine-containing dipeptide analogues is presented. A variety of polymer-bound dipeptide analogues with L-ornithine at the Nor C-terminus was formed on the solid support, and the conversion of polymer-bound ornithine to N(ω)-propylarginine generated the desired dipeptides. 1H-Pyrazole-N-propyl- 1-carboxamidine was found to be an effective guanylating agent.

KW - Guanylating agent

KW - Propylarginine-containing dipeptides

KW - Solid-phase synthesis

UR - http://www.scopus.com/inward/record.url?scp=0032813815&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032813815&partnerID=8YFLogxK

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DO - 10.1055/s-1999-6077

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SP - 1495

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JO - Synthesis

JF - Synthesis

IS - SPEC. ISS.

ER -

Solid-phase syntheses of N(ω)-propylarginine-containing dipeptides, dipeptide esters, and dipeptide amides

Abstract

Keywords

ASJC Scopus subject areas

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