The first total synthesis of the natural cyclic heptapeptide scytalidamide A was achieved on solid phase using two different resins, a phenylalanine silane resin and a 4-methoxybenzaldehyde backbone linker resin. The synthetic product confirms the structure of the natural product reported in the preceding paper in this issue (Tan, L. T.; Cheng, X. C.; Jensen, P. R.; Fenical, W. J. Org. Chem. 2003, 68, 8767).
ASJC Scopus subject areas
- Organic Chemistry