Solid-Phase Total Synthesis of Scytalidamide A

Wenxin Gu, Richard B. Silverman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


The first total synthesis of the natural cyclic heptapeptide scytalidamide A was achieved on solid phase using two different resins, a phenylalanine silane resin and a 4-methoxybenzaldehyde backbone linker resin. The synthetic product confirms the structure of the natural product reported in the preceding paper in this issue (Tan, L. T.; Cheng, X. C.; Jensen, P. R.; Fenical, W. J. Org. Chem. 2003, 68, 8767).

Original languageEnglish (US)
Pages (from-to)8774-8779
Number of pages6
JournalJournal of Organic Chemistry
Issue number23
StatePublished - Nov 14 2003

ASJC Scopus subject areas

  • Organic Chemistry

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