Solifenacin objectively decreases urinary sensation in women with overactive bladder syndrome

Lior Lowenstein*, Kimberly Kenton, Elizabeth R. Mueller, Linda Brubaker, Edmond Sabo, Ramón A. Durazo-Arivzu, Mary P. FitzGerald

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Purpose To evaluate the test-retest reliability of a device that measures urinary sensation during cystometry, and to use that device to determine whether treatment of overactive bladder syndrome (OAB) with solifenacin is associated with a change in urinary sensation. Methods Overall 15 women were recruited for this study, ten women with OAB and urodynamically demonstrated detrusor overactivity and five controls without OAB underwent filling cystometry twice with contemporaneous, continuous recording of urinary sensation. Women with OAB received solifenacin 10 mg daily during the weeks between testing. We compared the areas under the initial and repeat sensation-volume curves. Results While taking solifenacin, the maximum cystometric capacity increased from 329 ± 168 ml to 464 ± 123 ml (P < 0.002), and the area under the bladder volume-sensation curve decreased (P < 0.0001). Untreated controls did not exhibit these changes. Conclusion We present psychometric data demonstrating improved bladder sensation during the treatment of OAB with solifenacin. If clinical correlations are confirmed by future study, such urinary sensation measures may prove useful as assessment, treatment predictor, or outcome measures in OAB research and/or clinical care.

Original languageEnglish (US)
Pages (from-to)425-429
Number of pages5
JournalInternational urology and nephrology
Volume44
Issue number2
DOIs
StatePublished - Apr 1 2012

Keywords

  • Antimuscarinic
  • Urgency
  • Urgeometer
  • Validity

ASJC Scopus subject areas

  • Nephrology
  • Urology

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