Solitary cutaneous myofibromas in adults: Report of six cases and discussion of differential diagnosis

Joan Guitart*, Jon H. Ritter, Mark R. Wick

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Six solitary, dermal or subcutaneous lesions occurring in adu lt patients are presented. These masses had a circumscribed, lobulated configuration; they were composed of fusiform and epithelioid cells that lacked atypical nuclear features. The pattern of growth featured fascicles and nests, a myxofibrous stroma, and prominent blood vessels with a focally 'hemangiopericytoid' appearance. Immunohistochemical analyses showed uniform reactivity for vimentin and alpha isoform-actin, with negativity for desmin and neural determinants. The overall appearance of the lesions was similar to that of 'infantile myofibromatosis,' and corresponded to previous descriptions of 'solitary myofibroma(tosis)' in adults. Immunophenotypic and ultrastructural support exists for a proposed myofibroblastic nature for such proliferations. Differential diagnostic considerations include neurothekeomas, plexiform fibrous histiocytomas, nodular fasciitis, cutaneous inflammatory pseudotumors, dermatomyofibromas, leiomyomas, and other forms of fibromatosis affecting the skin and superficial soft tissues.

Original languageEnglish (US)
Pages (from-to)437-444
Number of pages8
JournalJournal of cutaneous pathology
Issue number5
StatePublished - Nov 12 1996

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Dermatology


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