Solithromycin pharmacokinetics in plasma and dried blood spots and safety in adolescents

Daniel Gonzalez, Debra L. Palazzi, Leena Bhattacharya-Mithal, Amira Al-Uzri, Laura P. James, John Bradley, Natalie Neu, Theresa Jasion, Christoph P. Hornik, P. Brian Smith, Daniel K. Benjamin, Jr Kara Keedy, Prabhavathi Fernandes, Michael Cohen-Wolkowiez*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


We assessed the pharmacokinetics and safety of solithromycin, a fluoroketolide antibiotic, in a phase 1, open-label, multicenter study of 13 adolescents with suspected or confirmed bacterial infections. On days 3 to 5, the mean (standard deviation) maximum plasma concentration and area under the concentration versus time curve from 0 to 24 h were 0.74 μg/ml (0.61 μg/ml) and 9.28 μg · h/ml (6.30 μg · h/ml), respectively. The exposure and safety in this small cohort of adolescents were comparable to those for adults.

Original languageEnglish (US)
Pages (from-to)2572-2576
Number of pages5
JournalAntimicrobial agents and chemotherapy
Issue number4
StatePublished - Apr 2016

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Infectious Diseases
  • Pharmacology


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