Soluble HLA-G expression and renal graft acceptance

J. Qiu, P. I. Terasaki*, J. Miller, K. Mizutani, J. Cai, E. D. Carosella

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

89 Scopus citations

Abstract

HLA-G is a potentially interesting molecule associated with immunosuppressive function. We survey here the presence of soluble HLA-G (sHLA-G) in serial serum samples of renal transplants. A total of 330 sera of from 65 patients were tested for sHLA-G with ELISA. IgG/IgM antibodies to HLA, and MICA antibodies were also previously tested. After serial analysis of the 65 patients' 330 sera, 50% of 26 patients in functioning group had consistent sHLA-G expression or became positive, in comparison to 20.5% among 39 patients who rejected their transplants (p = 0.013). Thus sHLA-G was associated with functioning transplants. Eighty percent (77 of 96) of the HLA IgG positive sera had no sHLA-G expression, while 81.4% (83 of 102) of the HLA-G(+) sera had no HLA IgG (p = 0.005), which showed a negative association between sHLA-G and the presence of HLA IgG antibodies (which was previously been shown to be associated with failure). In this preliminary survey, sHLA-G was found in the serum of about 30% of renal transplant patients. sHLA-G had a negative association with allograft failure from chronic rejection, and a negative relationship with the production of HLA IgG antibodies. The significance of sHLA-G in renal transplants remains to be determined.

Original languageEnglish (US)
Pages (from-to)2152-2156
Number of pages5
JournalAmerican Journal of Transplantation
Volume6
Issue number9
DOIs
StatePublished - Sep 2006

Keywords

  • HLA antibody
  • HLA-G
  • Kidney transplantation
  • Rejection

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

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