Soluble serum interleukin 2 receptors in patients with asthma and allergic bronchopulmonary aspergillosis

J. E. Brown, Paul Allen Greenberger*, P. R. Yarnold

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Background: When T cells are activated, they produce two distinct surface receptors for interleukin 2 (IL2). One of these surface receptors is a 55-kD protein called IL2Ra which is released into peripheral blood following T cell activation. This soluble protein (sIL2R) can be measured in peripheral blood utilizing an ELISA, and thus provides an indirect indicator of T cell activation. Objective: The purpose of this study was to determine whether allergic bronchopulmonary aspergillosis (ABPA) was associated with increased soluble interleukin 2 receptors (sIL2R). Methods: We used the Immunoenzymometric Assay Kit (Immunotech International, Marseille, France) which had a monoclonal antibody to sIL2R to sensitize wells. To determine the degree of T cell activation in patients with asthma and ABPA, we have evaluated the concentration of sIL2R in the peripheral blood in four groups: (1) 26 nonatopic patients, (2) 39 patients skin test positive to Aspergillus who did not have serologic evidence of ABPA, (3) 14 patients with quiescent ABPA, and (4) 13 patients who had a new roentgenographic infiltrate from ABPA. Results: The mean concentration of sIL2R in the four groups were 24.5 pM (±16.7), 38.4 pM (±27.2), 48.4 pM (±28.2), and 64.8 pM (±33.0), respectively, Group 4 was greater than groups 1 and 2 (P < .05), and group 3 was greater than group 1 (P < .05). Conclusions: In patients with ABPA that is flaring, there is greater T cell activation than in either nonatopic controls or in patients who have asthma. Patients with ABPA in remission also had significantly greater T cell activation than nonatopic controls.

Original languageEnglish (US)
Pages (from-to)484-488
Number of pages5
JournalAnnals of Allergy, Asthma and Immunology
Volume74
Issue number6
StatePublished - Jan 1 1995

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pulmonary and Respiratory Medicine

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