Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors

Ming Zhang, Yuxuan Wang, Sian Jones, Mark Sausen, Kevin McMahon, Rajni Sharma, Qing Wang, Allan J. Belzberg, Kaisorn Chaichana, Gary L. Gallia, Ziya L. Gokaslan, Greg J. Riggins, Jean Paul Wolinksy, Laura D. Wood, Elizabeth A. Montgomery, Ralph H. Hruban, Kenneth W. Kinzler, Nickolas Papadopoulos, Bert Vogelstein, Chetan Bettegowda*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

139 Scopus citations

Abstract

Neurofibromatosis 1 is a hereditary syndrome characterized by the development of numerous benign neurofibromas, a small subset of which progress to malignant peripheral nerve sheath tumors (MPNSTs). To better understand the genetic basis for MPNSTs, we performed genome-wide or targeted sequencing on 50 cases. Sixteen MPNSTs but none of the neurofibromas tested were found to have somatic mutations in SUZ12, implicating it as having a central role in malignant transformation.

Original languageEnglish (US)
Pages (from-to)1170-1172
Number of pages3
JournalNature Genetics
Volume46
Issue number11
DOIs
StatePublished - Nov 5 2014

ASJC Scopus subject areas

  • Genetics

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