Some new multiple-test procedures for dose finding

C. W. Dunnett*, A. C. Tamhane

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

In Tamhane, Hochberg, and Dunnett (1) we focused primarily on stepdown test procedures based on contrasts among the sample means to find the minimum effective dose in a dose-response study. In the present article we use the global tests of Bartholomew (2,3) and Hayter (4) in these step-down procedures. We also propose a new step-down procedure that permits tests based on a class of contrasts [step and basin contrasts of Ruberg (5) are examples of such contrasts] that could not be used with the step-down procedures studied in our previous paper because of lack of control of the familywise error rate. A simulation study to compare the four procedures proposed in the present paper with the top four procedures from the previous article is carded out. It is found that the step-down procedure based on Bartholomew's test and the new step-down procedure based on step and modified basin contrasts generally perform better than the other procedures for a wide range of dose-response profiles.

Original languageEnglish (US)
Pages (from-to)353-366
Number of pages14
JournalJournal of Biopharmaceutical Statistics
Volume8
Issue number3
DOIs
StatePublished - Jan 1 1998

Keywords

  • Dose response
  • Familywise error rate
  • Inference under order restrictions
  • Minimum effective dose
  • Multiple comparisons
  • Stepwise multiple testing procedures

ASJC Scopus subject areas

  • Statistics and Probability
  • Pharmacology
  • Pharmacology (medical)

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