Some new multiple-test procedures for dose finding

C. W. Dunnett*, A. C. Tamhane

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

In Tamhane, Hochberg, and Dunnett (1) we focused primarily on stepdown test procedures based on contrasts among the sample means to find the minimum effective dose in a dose-response study. In the present article we use the global tests of Bartholomew (2,3) and Hayter (4) in these step-down procedures. We also propose a new step-down procedure that permits tests based on a class of contrasts [step and basin contrasts of Ruberg (5) are examples of such contrasts] that could not be used with the step-down procedures studied in our previous paper because of lack of control of the familywise error rate. A simulation study to compare the four procedures proposed in the present paper with the top four procedures from the previous article is carded out. It is found that the step-down procedure based on Bartholomew's test and the new step-down procedure based on step and modified basin contrasts generally perform better than the other procedures for a wide range of dose-response profiles.

Original languageEnglish (US)
Pages (from-to)353-366
Number of pages14
JournalJournal of Biopharmaceutical Statistics
Volume8
Issue number3
DOIs
StatePublished - 1998

Keywords

  • Dose response
  • Familywise error rate
  • Inference under order restrictions
  • Minimum effective dose
  • Multiple comparisons
  • Stepwise multiple testing procedures

ASJC Scopus subject areas

  • Statistics and Probability
  • Pharmacology
  • Pharmacology (medical)

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