Studies were made on plasma obtained during the defibrinated state with Ancrod, the thrombin-like enzyme from the venom of Agkistrodon rhodostoma. The results show that fibrinogen degradation products persist throughout the period and disappear when treatment is terminated. SDS gels show that the fibrinogen remaining appears to have defective alpha chains but again the molecule returns to normal after completion of treatment. There was no increase in fibrinolytic activity in plasma or urine as measured by the fibrin plate method.
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