Some studies on proteins in the defibrinated state during ancrod (A38414) studies in normal humans

Grant H. Barlow; S. L. Lazer; R. Finley; H. C. Kwaan; J. F. Donahoe

doi:10.1016/0049-3848(73)90023-6

Some studies on proteins in the defibrinated state during ancrod (A38414) studies in normal humans

Grant H. Barlow^*, S. L. Lazer, R. Finley, H. C. Kwaan, J. F. Donahoe

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Studies were made on plasma obtained during the defibrinated state with Ancrod, the thrombin-like enzyme from the venom of Agkistrodon rhodostoma. The results show that fibrinogen degradation products persist throughout the period and disappear when treatment is terminated. SDS gels show that the fibrinogen remaining appears to have defective alpha chains but again the molecule returns to normal after completion of treatment. There was no increase in fibrinolytic activity in plasma or urine as measured by the fibrin plate method.

Original language	English (US)
Pages (from-to)	115-122
Number of pages	8
Journal	Thrombosis Research
Volume	2
Issue number	2
DOIs	https://doi.org/10.1016/0049-3848(73)90023-6
State	Published - Jan 1 1973
Externally published	Yes

ASJC Scopus subject areas

Hematology

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10.1016/0049-3848(73)90023-6

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AU - Barlow, Grant H.

AU - Lazer, S. L.

AU - Finley, R.

AU - Kwaan, H. C.

AU - Donahoe, J. F.

PY - 1973/1/1

Y1 - 1973/1/1

N2 - Studies were made on plasma obtained during the defibrinated state with Ancrod, the thrombin-like enzyme from the venom of Agkistrodon rhodostoma. The results show that fibrinogen degradation products persist throughout the period and disappear when treatment is terminated. SDS gels show that the fibrinogen remaining appears to have defective alpha chains but again the molecule returns to normal after completion of treatment. There was no increase in fibrinolytic activity in plasma or urine as measured by the fibrin plate method.

AB - Studies were made on plasma obtained during the defibrinated state with Ancrod, the thrombin-like enzyme from the venom of Agkistrodon rhodostoma. The results show that fibrinogen degradation products persist throughout the period and disappear when treatment is terminated. SDS gels show that the fibrinogen remaining appears to have defective alpha chains but again the molecule returns to normal after completion of treatment. There was no increase in fibrinolytic activity in plasma or urine as measured by the fibrin plate method.

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Some studies on proteins in the defibrinated state during ancrod (A38414) studies in normal humans

Abstract

ASJC Scopus subject areas

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