Some studies on proteins in the defibrinated state during ancrod (A38414) studies in normal humans

Grant H. Barlow*, S. L. Lazer, R. Finley, Hau C. Kwaan, J. F. Donahoe

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Studies were made on plasma obtained during the defibrinated state with Ancrod, the thrombin-like enzyme from the venom of Agkistrodon rhodostoma. The results show that fibrinogen degradation products persist throughout the period and disappear when treatment is terminated. SDS gels show that the fibrinogen remaining appears to have defective alpha chains but again the molecule returns to normal after completion of treatment. There was no increase in fibrinolytic activity in plasma or urine as measured by the fibrin plate method.

Original languageEnglish (US)
Pages (from-to)115-122
Number of pages8
JournalThrombosis Research
Volume2
Issue number2
DOIs
StatePublished - Jan 1 1973

ASJC Scopus subject areas

  • Hematology

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