Abstract
Progress in understanding the molecular biology of neoplasms has been driven by remarkable improvements in molecular biology techniques, creating a rapidly moving field in which even subspecialists struggle to keep abreast. Nowhere is this more clearly demonstrated than in neuro-oncology, wherein molecular diagnostics can wring more clinically useful information out of small biopsies than ever. The biologic and practical aspects of 4 key molecular biomarkers in gliomas are discussed, including 2 that have been known for some time (1p/19q codeletion and epidermal growth factor receptor [EGFR] amplification) as well as 2 whose relevance was discovered via advanced whole-genome assays (IDH1/2 mutations and BRAF alterations).
Original language | English (US) |
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Pages (from-to) | 919-939 |
Number of pages | 21 |
Journal | Surgical Pathology Clinics |
Volume | 5 |
Issue number | 4 |
DOIs | |
State | Published - Dec 1 2012 |
Keywords
- Biomarkers
- Central nervous system cancer
- Glioma
- Molecular pathology
- Neuro-oncology
ASJC Scopus subject areas
- Surgery
- Pathology and Forensic Medicine