Sorting and transport of alpha herpesviruses in axons

M. J. Tomishima, G. A. Smith, L. W. Enquist*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

104 Scopus citations

Abstract

The alpha herpesviruses, a subfamily of the herpesviruses, are neurotropic pathogens found associated with most mammalian species. The prototypic member of this subfamily is herpes simplex virus type 1, the causative agent of recurrent cold sores in humans. The mild nature of this disease is a testament to the complex and highly regulated life cycle of the alpha herpesviruses. The cellular mechanisms used by these viruses to disseminate infection in the nervous system are beginning to be understood. Here, we overview the life cycle of alpha herpesviruses with an emphasis on assembly and transport of viral particles in neurons.

Original languageEnglish (US)
Pages (from-to)429-436
Number of pages8
JournalTraffic
Volume2
Issue number7
DOIs
StatePublished - 2001

Keywords

  • Agress
  • Assembly
  • Axon
  • Entry
  • HSV
  • Herpes
  • Herpesvirus
  • Microtubules
  • Motor
  • Neuron
  • PRVZ
  • Transport
  • Vesicle

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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