Sorting Sox: Diverse Roles for Sox Transcription Factors During Neural Crest and Craniofacial Development

Elizabeth N. Schock, Carole LaBonne*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Sox transcription factors play many diverse roles during development, including regulating stem cell states, directing differentiation, and influencing the local chromatin landscape. Of the twenty vertebrate Sox factors, several play critical roles in the development the neural crest, a key vertebrate innovation, and the subsequent formation of neural crest-derived structures, including the craniofacial complex. Herein, we review the specific roles for individual Sox factors during neural crest cell formation and discuss how some factors may have been essential for the evolution of the neural crest. Additionally, we describe how Sox factors direct neural crest cell differentiation into diverse lineages such as melanocytes, glia, and cartilage and detail their involvement in the development of specific craniofacial structures. Finally, we highlight several SOXopathies associated with craniofacial phenotypes.

Original languageEnglish (US)
Article number606889
JournalFrontiers in Physiology
Volume11
DOIs
StatePublished - Dec 8 2020

Keywords

  • SoxB1
  • SoxE
  • craniofacial development
  • neural crest
  • stem cells

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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