TY - JOUR
T1 - Sorting the signals from the signals in the noisy environment of inflammation
AU - Muller, William A.
PY - 2011/4/26
Y1 - 2011/4/26
N2 - Necrotic cells release dozens, possibly hundreds, of molecules that stimulate the inflammatory response. Healthy cells in the environment react to these by secreting other inflammatory mediators to amplify the response. In response to acute necrotic injury in the liver, neutrophils follow a restricted set of molecular cues to move along the sinusoids through the inflamed tissue and into the zone of necrosis, as demonstrated by intravital microscopy to view leukocyte migration live and in real time. Necrosis initiates an intricate interplay between damage-associated molecular pattern molecules, stromal inflammatory cells, and neutrophils. This results in a series of clear molecular signals, enabling neutrophils to follow an intravascular chemokine gradient along the sinusoid in the region where blood still circulates and a formyl peptide gradient through the nonperfused region to the necrotic focus.
AB - Necrotic cells release dozens, possibly hundreds, of molecules that stimulate the inflammatory response. Healthy cells in the environment react to these by secreting other inflammatory mediators to amplify the response. In response to acute necrotic injury in the liver, neutrophils follow a restricted set of molecular cues to move along the sinusoids through the inflamed tissue and into the zone of necrosis, as demonstrated by intravital microscopy to view leukocyte migration live and in real time. Necrosis initiates an intricate interplay between damage-associated molecular pattern molecules, stromal inflammatory cells, and neutrophils. This results in a series of clear molecular signals, enabling neutrophils to follow an intravascular chemokine gradient along the sinusoid in the region where blood still circulates and a formyl peptide gradient through the nonperfused region to the necrotic focus.
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U2 - 10.1126/scisignal.2002051
DO - 10.1126/scisignal.2002051
M3 - Short survey
C2 - 21521878
AN - SCOPUS:79955432698
VL - 4
JO - Science's STKE : signal transduction knowledge environment
JF - Science's STKE : signal transduction knowledge environment
SN - 1937-9145
IS - 170
M1 - pe23
ER -