Sox1 acts through multiple independent pathways to promote neurogenesis

Lixin Kan*, Nipan Israsena, Zuoli Zhang, Min Hu, Li Ru Zhao, Ali Jalali, Vibhu Sahni, John A. Kessler

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

133 Scopus citations

Abstract

Although Sox1, Sox2, and Sox3 are all part of the Sox-B1 group of transcriptional regulators, only Sox1 appears to play a direct role in neural cell fate determination and differentiation. We find that overexpression of Sox1 but not Sox2 or Sox3 in cultured neural progenitor cells is sufficient to induce neuronal lineage commitment. Sox1 binds directly to the Hes1 promoter and suppresses Hes1 transcription, thus attenuating Notch signaling. Sox1 also binds to β-catenin and suppresses β-catenin-mediated TCF/LEF signaling, thus potentially attenuating the wnt signaling pathway. The C-terminus of Sox1 is required for both of these interactions. Sox1 also promotes exit of cells from cell cycle and up-regulates transcription of the proneural bHLH transcription factor neurogenin1 (ngn1). These observations suggest that Sox1 works through multiple independent pathways to promote neuronal cell fate determination and differentiation.

Original languageEnglish (US)
Pages (from-to)580-594
Number of pages15
JournalDevelopmental Biology
Volume269
Issue number2
DOIs
StatePublished - May 15 2004

Keywords

  • Cell cycle
  • Hes1
  • Neurogenesis
  • Neurogenin1
  • Notch
  • Retinoic acid (RA)
  • Sox1
  • Sox2
  • Sox3
  • TCF/LEF signaling
  • bHLH
  • β-catenin

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Sox1 acts through multiple independent pathways to promote neurogenesis'. Together they form a unique fingerprint.

Cite this