Sox5 is a DNA-Binding cofactor for BMP r-smads that directs target specificity during patterning of the early ectoderm

Kara Nordin, Carole LaBonne*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

The SoxD factor, Sox5, is expressed in ectodermal cells at times and places where BMP signaling is active, including the cells of the animal hemisphere at blastula stages and the neural plate border and neural crest at neurula stages. Sox5 is required for proper ectoderm development, and deficient embryos display patterning defects characteristic of perturbations of BMP signaling, including loss of neural crest and epidermis and expansion of the neural plate. We show that Sox5 is essential for activation of BMP target genes in embryos and explants, that it physically interacts with BMP R-Smads, and that it is essential for recruitment of Smad1/4 to BMP regulatory elements. Our findings identify Sox5 as the long-sought DNA-binding partner for BMP R-Smads essential to plasticity and pattern in the early ectoderm.

Original languageEnglish (US)
Pages (from-to)374
Number of pages1
JournalDevelopmental Cell
Volume31
Issue number3
DOIs
StatePublished - Nov 10 2014

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Sox5 is a DNA-Binding cofactor for BMP r-smads that directs target specificity during patterning of the early ectoderm'. Together they form a unique fingerprint.

Cite this