Spared discrimination and impaired reversal eyeblink conditioning in patients with temporal lobe amnesia

M. C. Carrillo*, J. D.E. Gabrieli, R. O. Hopkins, R. McGlinchey-Berroth, C. B. Fortier, R. P. Kesner, J. F. Disterhoft

*Corresponding author for this work

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

The effect of medial temporal lobe damage on a 2-tone delay discrimination and reversal paradigm was examined in human classical eyeblink conditioning. Eight medial temporal lobe amnesic patients and their demographically matched controls were compared. Amnesic patients were able to distinguish between 2 tones during the initial discrimination phase of the experiment almost as well as control participants. Amnesic patients were not able to reverse the previously acquired 2-tone discrimination. In contrast, the control participants showed improved discrimination performance after the reversal of the tones. These findings support the hypothesis that the hippocampus and associated temporal lobe regions play a role in eyeblink conditioning that becomes essential in more complex versions of the task, such as the reversal of an acquired 2-tone discrimination.

Original languageEnglish (US)
Pages (from-to)1171-1179
Number of pages9
JournalBehavioral Neuroscience
Volume115
Issue number6
DOIs
StatePublished - 2001

ASJC Scopus subject areas

  • Behavioral Neuroscience

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    Carrillo, M. C., Gabrieli, J. D. E., Hopkins, R. O., McGlinchey-Berroth, R., Fortier, C. B., Kesner, R. P., & Disterhoft, J. F. (2001). Spared discrimination and impaired reversal eyeblink conditioning in patients with temporal lobe amnesia. Behavioral Neuroscience, 115(6), 1171-1179. https://doi.org/10.1037/0735-7044.115.6.1171