Spatial and temporal sequence of events in cell adhesion: From molecular recognition to focal adhesion assembly

Miriam Cohen, Derk Joester, Benjamin Geiger*, Lia Addadi

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

105 Scopus citations

Abstract

A new concept that attributes a pivotal role to the pericellular coat in the regulation of the early stages of cell adhesion is presented. Quick, adaptable, and transient adhesion through multiple cooperative weak interactions provides the cell with an additional level of modulation in the decision-making process that precedes the commitment to adhesion at a particular site. Hyaluronan emerges as a modulator of cell adhesion in certain cells, mediating binding or repulsion through its polyelectrolyte character, in addition to its chirality and molecular-recognition properties. The biophysical properties of hyaluronan as well as its ultrastructural organization are analyzed in relation to this proposed function.

Original languageEnglish (US)
Pages (from-to)1393-1399
Number of pages7
JournalChemBioChem
Volume5
Issue number10
DOIs
StatePublished - Oct 4 2004

Keywords

  • Carbohydrates
  • Cell adhesion
  • Hyaluronan
  • Pericellular coat
  • Polyelectrolyte brush

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Organic Chemistry

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