TY - JOUR
T1 - Spatial organization of ubiquitin ligase pathways orchestrates neuronal connectivity
AU - Yamada, Tomoko
AU - Yang, Yue
AU - Bonni, Azad
PY - 2013/4
Y1 - 2013/4
N2 - Recent studies have revealed that E3 ubiquitin ligases have essential functions in the establishment of neuronal circuits. Strikingly, a common emerging theme in these studies is that spatial organization of E3 ubiquitin ligases plays a critical role in the control of neuronal morphology and connectivity. E3 ubiquitin ligases localize to the nucleus, centrosome, Golgi apparatus, axon and dendrite cytoskeleton, and synapses in neurons. Localization of ubiquitin ligases within distinct subcellular compartments may facilitate neuronal responses to extrinsic cues and the ubiquitination of local substrates. Here, we review the functions of neuronal E3 ubiquitin ligases at distinct subcellular locales and explore how they regulate neuronal morphology and function in the nervous system.
AB - Recent studies have revealed that E3 ubiquitin ligases have essential functions in the establishment of neuronal circuits. Strikingly, a common emerging theme in these studies is that spatial organization of E3 ubiquitin ligases plays a critical role in the control of neuronal morphology and connectivity. E3 ubiquitin ligases localize to the nucleus, centrosome, Golgi apparatus, axon and dendrite cytoskeleton, and synapses in neurons. Localization of ubiquitin ligases within distinct subcellular compartments may facilitate neuronal responses to extrinsic cues and the ubiquitination of local substrates. Here, we review the functions of neuronal E3 ubiquitin ligases at distinct subcellular locales and explore how they regulate neuronal morphology and function in the nervous system.
KW - Axon growth
KW - Dendrite morphogenesis
KW - E3 ubiquitin ligase
KW - Subcellular localization
KW - Synapse differentiation
UR - http://www.scopus.com/inward/record.url?scp=84875853339&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84875853339&partnerID=8YFLogxK
U2 - 10.1016/j.tins.2012.12.004
DO - 10.1016/j.tins.2012.12.004
M3 - Review article
C2 - 23332798
AN - SCOPUS:84875853339
VL - 36
SP - 218
EP - 226
JO - Trends in Neurosciences
JF - Trends in Neurosciences
SN - 0378-5912
IS - 4
ER -