Abstract
Recent studies have revealed that E3 ubiquitin ligases have essential functions in the establishment of neuronal circuits. Strikingly, a common emerging theme in these studies is that spatial organization of E3 ubiquitin ligases plays a critical role in the control of neuronal morphology and connectivity. E3 ubiquitin ligases localize to the nucleus, centrosome, Golgi apparatus, axon and dendrite cytoskeleton, and synapses in neurons. Localization of ubiquitin ligases within distinct subcellular compartments may facilitate neuronal responses to extrinsic cues and the ubiquitination of local substrates. Here, we review the functions of neuronal E3 ubiquitin ligases at distinct subcellular locales and explore how they regulate neuronal morphology and function in the nervous system.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 218-226 |
| Number of pages | 9 |
| Journal | Trends in Neurosciences |
| Volume | 36 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 2013 |
Funding
This work was supported by the National Institutes of Health (grant NS051255 to A.B.), the Japan Society for the Promotion of Science (T.Y.), and the Albert J. Ryan Foundation, the National Science Foundation, and a Lefler fellowship (Y.Y.). We thank members of the Bonni laboratory for helpful discussions and critical reading of the manuscript.
Keywords
- Axon growth
- Dendrite morphogenesis
- E3 ubiquitin ligase
- Subcellular localization
- Synapse differentiation
ASJC Scopus subject areas
- General Neuroscience