Spatial serial order processing in schizophrenia

David Fraser; Sohee Park; Gina Clark; Daniel Yohanna; James C. Houk

doi:10.1016/j.schres.2003.09.019

Spatial serial order processing in schizophrenia

David Fraser, Sohee Park, Gina Clark, Daniel Yohanna, James C. Houk^*

^*Corresponding author for this work

Neuroscience

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

The aim of this study was to examine serial order processing deficits in 21 schizophrenia patients and 16 age- and education-matched healthy controls. In a spatial serial order working memory task, one to four spatial targets were presented in a randomized sequence. Subjects were required to remember the locations and the order in which the targets were presented. Patients showed a marked deficit in ability to remember the sequences compared with controls. Increasing the number of targets within a sequence resulted in poorer memory performance for both control and schizophrenia subjects, but the effect was much more pronounced in the patients. Targets presented at the end of a long sequence were more vulnerable to memory error in schizophrenia patients. Performance deficits were not attributable to motor errors, but to errors in target choice. The results support the idea that the memory errors seen in schizophrenia patients may be due to saturating the working memory network at relatively low levels of memory load.

Original language	English (US)
Pages (from-to)	203-213
Number of pages	11
Journal	Schizophrenia Research
Volume	70
Issue number	2-3
DOIs	https://doi.org/10.1016/j.schres.2003.09.019
State	Published - Oct 1 2004

Funding

Supported in part by NIMH (MH-48185) and NINDS (NS-044837) to Dr. Houk, and by NIMH (MH 058406) and a NARSAD Young Investigator Award to Dr. Park. The authors wish to thank Ms. Paula Han, Drs. Deborah Levy, Philip Holzman and Ross Baldessarini for their advice.

Keywords

Saturation
Schizophrenia
Sequence
Serial order
Working memory

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/j.schres.2003.09.019

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N2 - The aim of this study was to examine serial order processing deficits in 21 schizophrenia patients and 16 age- and education-matched healthy controls. In a spatial serial order working memory task, one to four spatial targets were presented in a randomized sequence. Subjects were required to remember the locations and the order in which the targets were presented. Patients showed a marked deficit in ability to remember the sequences compared with controls. Increasing the number of targets within a sequence resulted in poorer memory performance for both control and schizophrenia subjects, but the effect was much more pronounced in the patients. Targets presented at the end of a long sequence were more vulnerable to memory error in schizophrenia patients. Performance deficits were not attributable to motor errors, but to errors in target choice. The results support the idea that the memory errors seen in schizophrenia patients may be due to saturating the working memory network at relatively low levels of memory load.

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Spatial serial order processing in schizophrenia

Abstract

Funding

Keywords

ASJC Scopus subject areas

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