Spatiotemporal control over the host-guest characteristics of a stimulus-triggerable trifunctional polymer assembly

Piyachai Khomein; Kingshuk Dutta; Karthikeyan Gnanasekaran; Nathan C. Gianneschi; S. Thayumanavan

doi:10.1039/c8py01788c

Spatiotemporal control over the host-guest characteristics of a stimulus-triggerable trifunctional polymer assembly

Piyachai Khomein, Kingshuk Dutta, Karthikeyan Gnanasekaran, Nathan C. Gianneschi, S. Thayumanavan^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The positional effect of stimuli-responsive units in tri-component copolymer vesicles is studied to explore variations in the host-guest properties of the assembly. We study this by placing pH-responsive diisopropylaminoethyl moieties in three distinct locations of a block copolymer assembly. In two of the three variations, these functionalities were randomly distributed in the hydrophobic or the hydrophilic domains of an amphiphilic diblock copolymer. In a third variation, this responsive functionality was incorporated as the middle block in a triblock copolymer. The results reveal that the solvent exposure of the responsive units holds the key for controlling the rate of molecular release from these polymer vesicles. The study also shows that equilibrium changes in the morphology of an assembly are not good indicators of the responsive host-guest properties of a polymer assembly.

Original language	English (US)
Pages (from-to)	1423-1430
Number of pages	8
Journal	Polymer Chemistry
Volume	10
Issue number	12
DOIs	https://doi.org/10.1039/c8py01788c
State	Published - Mar 28 2019

ASJC Scopus subject areas

Bioengineering
Biochemistry
Polymers and Plastics
Organic Chemistry

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10.1039/c8py01788c

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title = "Spatiotemporal control over the host-guest characteristics of a stimulus-triggerable trifunctional polymer assembly",

abstract = "The positional effect of stimuli-responsive units in tri-component copolymer vesicles is studied to explore variations in the host-guest properties of the assembly. We study this by placing pH-responsive diisopropylaminoethyl moieties in three distinct locations of a block copolymer assembly. In two of the three variations, these functionalities were randomly distributed in the hydrophobic or the hydrophilic domains of an amphiphilic diblock copolymer. In a third variation, this responsive functionality was incorporated as the middle block in a triblock copolymer. The results reveal that the solvent exposure of the responsive units holds the key for controlling the rate of molecular release from these polymer vesicles. The study also shows that equilibrium changes in the morphology of an assembly are not good indicators of the responsive host-guest properties of a polymer assembly.",

author = "Piyachai Khomein and Kingshuk Dutta and Karthikeyan Gnanasekaran and Gianneschi, {Nathan C.} and S. Thayumanavan",

note = "Funding Information: We thank the National Science Foundation (CHE-1745097) for funding. Publisher Copyright: {\textcopyright} 2019 The Royal Society of Chemistry.",

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AU - Khomein, Piyachai

AU - Dutta, Kingshuk

AU - Gnanasekaran, Karthikeyan

AU - Gianneschi, Nathan C.

AU - Thayumanavan, S.

PY - 2019/3/28

Y1 - 2019/3/28

N2 - The positional effect of stimuli-responsive units in tri-component copolymer vesicles is studied to explore variations in the host-guest properties of the assembly. We study this by placing pH-responsive diisopropylaminoethyl moieties in three distinct locations of a block copolymer assembly. In two of the three variations, these functionalities were randomly distributed in the hydrophobic or the hydrophilic domains of an amphiphilic diblock copolymer. In a third variation, this responsive functionality was incorporated as the middle block in a triblock copolymer. The results reveal that the solvent exposure of the responsive units holds the key for controlling the rate of molecular release from these polymer vesicles. The study also shows that equilibrium changes in the morphology of an assembly are not good indicators of the responsive host-guest properties of a polymer assembly.

AB - The positional effect of stimuli-responsive units in tri-component copolymer vesicles is studied to explore variations in the host-guest properties of the assembly. We study this by placing pH-responsive diisopropylaminoethyl moieties in three distinct locations of a block copolymer assembly. In two of the three variations, these functionalities were randomly distributed in the hydrophobic or the hydrophilic domains of an amphiphilic diblock copolymer. In a third variation, this responsive functionality was incorporated as the middle block in a triblock copolymer. The results reveal that the solvent exposure of the responsive units holds the key for controlling the rate of molecular release from these polymer vesicles. The study also shows that equilibrium changes in the morphology of an assembly are not good indicators of the responsive host-guest properties of a polymer assembly.

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Spatiotemporal control over the host-guest characteristics of a stimulus-triggerable trifunctional polymer assembly

Abstract

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