Spatiotemporal organization of cytoskeletal strain induced by external fluid mechanical forces

Brian P. Helmke*, Amy B. Rosen, David B. Thakker, Robert Goldman, Peter F. Davies

*Corresponding author for this work

Research output: Contribution to journalConference articlepeer-review

Abstract

Intermediate filament (IF) displacement and strain field as a function of time and subcellular spatial position were studied. Displacement index (DI) was measured to study the degree of movement of IF segments at high spatial resolution. Results showed that hemodynamic shear stress on the lumenal surface of endothelial cells (EC) regulates vessel wall physiology through multiple intracellular networks.

Original languageEnglish (US)
Pages (from-to)705-706
Number of pages2
JournalAmerican Society of Mechanical Engineers, Bioengineering Division (Publication) BED
Volume50
StatePublished - Dec 1 2001
EventProceedings of the 2001 Bioengineering Conference - Snowbird, UT, United States
Duration: Jun 27 2001Jul 1 2001

ASJC Scopus subject areas

  • Engineering(all)

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