Special article: Antineoplastic drug resistance and DNA repair

R. K. Burt*, M. C. Poirier, C. J. Link, V. A. Bohr

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Important aspects of the DNA repair mechanisms in mammalian, and especially human, cells are reviewed. The DNA repair processes are essential in the maintenance of the integrity of the DNA and in the defense against cancer. It has recently been discovered that the DNA repair efficiency differs in different regions of the genome and that active genes are preferentially repaired. There is mounting evidence that DNA repair processes play a role in the development of drug resistance by tumor cells. We will discuss such data as well as further approaches to clarify the relationship between DNA repair and antineoplastic drug resistance. Specifically, there is an increasing need to investigate the intragenomic heterogeneity of DNA repair and correlate the repair efficiency in specific genes to aspects of drug resistance. We also discuss the therapeutic potential of inhibiting the DNA repair processes and thereby possibly overcoming drug resistance.

Original languageEnglish (US)
Pages (from-to)325-334
Number of pages10
JournalAnnals of Oncology
Volume2
Issue number5
DOIs
StatePublished - May 1991

ASJC Scopus subject areas

  • Hematology
  • Oncology

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