Special properties of cholinesterases in the cerebral cortex of Alzheimer's disease

Changiz Geula; Marsel Mesulam

doi:10.1016/0006-8993(89)90419-8

Special properties of cholinesterases in the cerebral cortex of Alzheimer's disease

Changiz Geula^*, Marsel Mesulam

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

123 Scopus citations

Abstract

Selective cholinesterase inhibitors such as BW284C51 and iso-OMPA showed that the plaques and tangles of Alzheimer's disease contain acetylcholinesterase and butyrylcholinesterase activity. In comparison to the cholinesterases of the normal brain, the plaque and tangle-bound cholinesterases in Alzheimer's disease display major shifts in optimum pH and inhibitor sensitivity.

Original language	English (US)
Pages (from-to)	185-189
Number of pages	5
Journal	Brain research
Volume	498
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(89)90419-8
State	Published - Sep 25 1989

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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title = "Special properties of cholinesterases in the cerebral cortex of Alzheimer's disease",

abstract = "Selective cholinesterase inhibitors such as BW284C51 and iso-OMPA showed that the plaques and tangles of Alzheimer's disease contain acetylcholinesterase and butyrylcholinesterase activity. In comparison to the cholinesterases of the normal brain, the plaque and tangle-bound cholinesterases in Alzheimer's disease display major shifts in optimum pH and inhibitor sensitivity.",

author = "Changiz Geula and Marsel Mesulam",

note = "Funding Information: We would like to thank Leah Christie and Kristin Loud for expert secretarial and technical assistance. We are grateful to Drs. Catherine Joachim, Bruce Price and William Schoene for providing human brain tissue. Supported in part by an NRSA award (AG05455), an Aizheimer's Disease Research Center grant (AG05134), the Alzheimer's Disease and Related Disorders Association and by a Javits Neuroscience Investigator Award (NS20285).",

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AU - Mesulam, Marsel

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AB - Selective cholinesterase inhibitors such as BW284C51 and iso-OMPA showed that the plaques and tangles of Alzheimer's disease contain acetylcholinesterase and butyrylcholinesterase activity. In comparison to the cholinesterases of the normal brain, the plaque and tangle-bound cholinesterases in Alzheimer's disease display major shifts in optimum pH and inhibitor sensitivity.

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