Special properties of cholinesterases in the cerebral cortex of Alzheimer's disease

Changiz Geula*, Marsel Mesulam

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

123 Scopus citations

Abstract

Selective cholinesterase inhibitors such as BW284C51 and iso-OMPA showed that the plaques and tangles of Alzheimer's disease contain acetylcholinesterase and butyrylcholinesterase activity. In comparison to the cholinesterases of the normal brain, the plaque and tangle-bound cholinesterases in Alzheimer's disease display major shifts in optimum pH and inhibitor sensitivity.

Original languageEnglish (US)
Pages (from-to)185-189
Number of pages5
JournalBrain research
Volume498
Issue number1
DOIs
StatePublished - Sep 25 1989

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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