Species-specific uptake of DNA by gonococci is mediated by a 10-base-pair sequence

C. Elkins*, C. E. Thomas, H. S. Seifert, P. F. Sparling

*Corresponding author for this work

Research output: Contribution to journalComment/debatepeer-review

165 Scopus citations


Piliated Neisseria gonorrhoeae are known to be transformed less readily if transforming DNA competes with DNA containing the 10-bp sequence GCCGTCTGAA. It has been postulated that the 10-bp sequence is a recognition sequence which is required for efficient DNA uptake. We show that the presence of various forms of this 10-bp sequence results in increased uptake of double-stranded DNA into a DNase-resistant state and allows genetic transformation by an otherwise nontransformable plasmid.

Original languageEnglish (US)
Pages (from-to)3911-3913
Number of pages3
JournalJournal of bacteriology
Issue number12
StatePublished - 1991

ASJC Scopus subject areas

  • Molecular Biology
  • Microbiology


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