Specificity of short-loop feedback of luteinizing hormone in the rabbit

Mark E. Molitch; M. Edmonds; J. C. Hendrick; P. Franchimont; W. D. Odell

doi:10.1159/000122904

Specificity of short-loop feedback of luteinizing hormone in the rabbit

Mark E. Molitch^*, M. Edmonds, J. C. Hendrick, P. Franchimont, W. D. Odell

^*Corresponding author for this work

Medicine, Endocrinology Division

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The specificity of the gonadotropin short-loop feedback mechanism was investigated in castrated rabbits by blood sampling from an indwelling jugular venous catheter for follicle-stimulating hormone (FSH) after the intravenous administration of purified human luteinizing hormone (hLH). Although we have previously shown that such hLH administration results in a decrease of rabbit LH, no decrease in rabbit FSH was seen in these experiments. This specificity of LH feedback is compatible with the site of feedback being at the (1) pituitary level or (2) at the hypothalamic level provided two separate LH and FSH releasing factors exist.

Original language	English (US)
Pages (from-to)	49-53
Number of pages	5
Journal	Neuroendocrinology
Volume	29
Issue number	1
DOIs	https://doi.org/10.1159/000122904
State	Published - 1979

Keywords

Feedback
Follicle-stimulating hormone
Gonadotropins
Luteinizing hormone
Short-loop

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology
Endocrine and Autonomic Systems
Cellular and Molecular Neuroscience

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abstract = "The specificity of the gonadotropin short-loop feedback mechanism was investigated in castrated rabbits by blood sampling from an indwelling jugular venous catheter for follicle-stimulating hormone (FSH) after the intravenous administration of purified human luteinizing hormone (hLH). Although we have previously shown that such hLH administration results in a decrease of rabbit LH, no decrease in rabbit FSH was seen in these experiments. This specificity of LH feedback is compatible with the site of feedback being at the (1) pituitary level or (2) at the hypothalamic level provided two separate LH and FSH releasing factors exist.",

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AU - Molitch, Mark E.

AU - Edmonds, M.

AU - Hendrick, J. C.

AU - Franchimont, P.

AU - Odell, W. D.

PY - 1979

Y1 - 1979

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AB - The specificity of the gonadotropin short-loop feedback mechanism was investigated in castrated rabbits by blood sampling from an indwelling jugular venous catheter for follicle-stimulating hormone (FSH) after the intravenous administration of purified human luteinizing hormone (hLH). Although we have previously shown that such hLH administration results in a decrease of rabbit LH, no decrease in rabbit FSH was seen in these experiments. This specificity of LH feedback is compatible with the site of feedback being at the (1) pituitary level or (2) at the hypothalamic level provided two separate LH and FSH releasing factors exist.

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KW - Gonadotropins

KW - Luteinizing hormone

KW - Short-loop

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Specificity of short-loop feedback of luteinizing hormone in the rabbit

Abstract

Keywords

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