Specificity of short-loop feedback of luteinizing hormone in the rabbit

Mark E. Molitch*, M. Edmonds, J. C. Hendrick, P. Franchimont, W. D. Odell

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The specificity of the gonadotropin short-loop feedback mechanism was investigated in castrated rabbits by blood sampling from an indwelling jugular venous catheter for follicle-stimulating hormone (FSH) after the intravenous administration of purified human luteinizing hormone (hLH). Although we have previously shown that such hLH administration results in a decrease of rabbit LH, no decrease in rabbit FSH was seen in these experiments. This specificity of LH feedback is compatible with the site of feedback being at the (1) pituitary level or (2) at the hypothalamic level provided two separate LH and FSH releasing factors exist.

Original languageEnglish (US)
Pages (from-to)49-53
Number of pages5
JournalNeuroendocrinology
Volume29
Issue number1
DOIs
StatePublished - 1979

Keywords

  • Feedback
  • Follicle-stimulating hormone
  • Gonadotropins
  • Luteinizing hormone
  • Short-loop

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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