@article{1be46ca487324f1eb9460998e65fe766,
title = "Spectral contrast optical coherence tomography angiography enables single-scan vessel imaging",
abstract = "Optical coherence tomography angiography relies on motion for contrast and requires at least two data acquisitions per pointwise scanning location. We present a method termed spectral contrast optical coherence tomography angiography using visible light that relies on the spectral signatures of blood for angiography from a single scan using endogenous contrast. We demonstrate the molecular sensitivity of this method, which enables lymphatic vessel, blood, and tissue discrimination.",
author = "Winkelmann, {James A.} and Aya Eid and Graham Spicer and Almassalha, {Luay M.} and Nguyen, {The Quyen} and Vadim Backman",
note = "Funding Information: We thank the O{\textquoteright}Halloran Group, Dr. Wenan Qiang, and the Center for Comparative Medicine at Northwestern University for donating mouse carcasses for imaging and Rongrong Liu for providing knowledge on traditional OCTA. Additionally, we would like to thank Professor Oliver Cossairt at Northwestern University for suggesting Fourier ring correlation analysis. Support for this work was provided by the National Science Foundation Graduate Research Fellowship and the National Institute of Health (R01CA200064, R01CA183101, R01CA173745, R01CA165309). An award of computer time was provided by the INCITE program. This research used resources of the Argonne Leadership Computing Facility, which is a DOE Office of Science User Facility supported under Contract DE-AC02-06CH11357.",
year = "2019",
month = dec,
day = "1",
doi = "10.1038/s41377-018-0117-7",
language = "English (US)",
volume = "8",
journal = "Light: Science and Applications",
issn = "2095-5545",
publisher = "Nature Publishing Group",
number = "1",
}