Spectral contrast optical coherence tomography angiography enables single-scan vessel imaging

James A. Winkelmann, Aya Eid, Graham Spicer, Luay M. Almassalha, The Quyen Nguyen, Vadim Backman*

*Corresponding author for this work

Research output: Contribution to journalLetter

5 Scopus citations

Abstract

Optical coherence tomography angiography relies on motion for contrast and requires at least two data acquisitions per pointwise scanning location. We present a method termed spectral contrast optical coherence tomography angiography using visible light that relies on the spectral signatures of blood for angiography from a single scan using endogenous contrast. We demonstrate the molecular sensitivity of this method, which enables lymphatic vessel, blood, and tissue discrimination.

Original languageEnglish (US)
Article number7
JournalLight: Science and Applications
Volume8
Issue number1
DOIs
StatePublished - Dec 1 2019

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

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