Spectral contrast optical coherence tomography angiography enables single-scan vessel imaging

James A. Winkelmann, Aya Eid, Graham Spicer, Luay M. Almassalha, The Quyen Nguyen, Vadim Backman

Research output: Contribution to journalLetter

Abstract

Optical coherence tomography angiography relies on motion for contrast and requires at least two data acquisitions per pointwise scanning location. We present a method termed spectral contrast optical coherence tomography angiography using visible light that relies on the spectral signatures of blood for angiography from a single scan using endogenous contrast. We demonstrate the molecular sensitivity of this method, which enables lymphatic vessel, blood, and tissue discrimination.

Original languageEnglish (US)
Article number7
JournalLight: Science and Applications
Volume8
Issue number1
DOIs
StatePublished - Dec 1 2019

Fingerprint

Angiography
angiography
Optical tomography
vessels
tomography
Imaging techniques
spectral signatures
spectral methods
blood vessels
Blood vessels
blood
data acquisition
discrimination
Data acquisition
Blood
Tissue
Scanning
scanning
sensitivity

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

Cite this

Winkelmann, James A. ; Eid, Aya ; Spicer, Graham ; Almassalha, Luay M. ; Nguyen, The Quyen ; Backman, Vadim. / Spectral contrast optical coherence tomography angiography enables single-scan vessel imaging. In: Light: Science and Applications. 2019 ; Vol. 8, No. 1.
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Spectral contrast optical coherence tomography angiography enables single-scan vessel imaging. / Winkelmann, James A.; Eid, Aya; Spicer, Graham; Almassalha, Luay M.; Nguyen, The Quyen; Backman, Vadim.

In: Light: Science and Applications, Vol. 8, No. 1, 7, 01.12.2019.

Research output: Contribution to journalLetter

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AU - Winkelmann, James A.

AU - Eid, Aya

AU - Spicer, Graham

AU - Almassalha, Luay M.

AU - Nguyen, The Quyen

AU - Backman, Vadim

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