Spectral karyotype analysis of T-cell acute leukemia

Janet D. Rowley; Shalini Reshmi; Katrin Carlson; Diane Roulston

doi:10.1182/blood.v93.6.2038.406a32_2038_2042

Spectral karyotype analysis of T-cell acute leukemia

Janet D. Rowley^*, Shalini Reshmi, Katrin Carlson, Diane Roulston

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

Analysis of 15 cases of T-cell acute lymphoblastic leukemia with spectral karyotyping (SKY), which can identify all chromosomes simultaneously, clarified the chromosome rearrangements in 3 cases and confirmed them in 11 others; no abnormal cells were identified in 1 case, which had only 10% abnormal cells. Five of the latter cases had a normal karyotype. Thus, the use of SKY substantially improves the precision of karyotype analysis of malignant cells, which in turn leads to a more accurate assessment of the genotypic abnormalities in those cells.

Original language	English (US)
Pages (from-to)	2038-2042
Number of pages	5
Journal	Blood
Volume	93
Issue number	6
DOIs	https://doi.org/10.1182/blood.v93.6.2038.406a32_2038_2042
State	Published - Mar 15 1999

ASJC Scopus subject areas

Biochemistry
Immunology
Hematology
Cell Biology

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10.1182/blood.v93.6.2038.406a32_2038_2042

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AU - Carlson, Katrin

AU - Roulston, Diane

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Y1 - 1999/3/15

N2 - Analysis of 15 cases of T-cell acute lymphoblastic leukemia with spectral karyotyping (SKY), which can identify all chromosomes simultaneously, clarified the chromosome rearrangements in 3 cases and confirmed them in 11 others; no abnormal cells were identified in 1 case, which had only 10% abnormal cells. Five of the latter cases had a normal karyotype. Thus, the use of SKY substantially improves the precision of karyotype analysis of malignant cells, which in turn leads to a more accurate assessment of the genotypic abnormalities in those cells.

AB - Analysis of 15 cases of T-cell acute lymphoblastic leukemia with spectral karyotyping (SKY), which can identify all chromosomes simultaneously, clarified the chromosome rearrangements in 3 cases and confirmed them in 11 others; no abnormal cells were identified in 1 case, which had only 10% abnormal cells. Five of the latter cases had a normal karyotype. Thus, the use of SKY substantially improves the precision of karyotype analysis of malignant cells, which in turn leads to a more accurate assessment of the genotypic abnormalities in those cells.

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Spectral karyotype analysis of T-cell acute leukemia

Abstract

ASJC Scopus subject areas

UN SDGs

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