Spectrally dependent roll-off in visible-light optical coherence tomography

Ian Rubinoff; Brian Soetikno; David A. Miller; Isabella Rischall; Amani Fawzi; Roman Kuranov; Hao F. Zhang

doi:10.1364/OL.389240

Spectrally dependent roll-off in visible-light optical coherence tomography

Ian Rubinoff, Brian Soetikno, David A. Miller, Isabella Rischall, Amani Fawzi, Roman Kuranov, Hao F. Zhang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Recent development of visible-light optical coherence tomography (vis-OCT) has introduced new applications for noninvasive spectroscopic imaging. However, the measured spectra may be altered by spectrally dependent roll-off (SDR). We formulated a mathematical model for SDR that accounted for nonuniform wavenumber spacing, optical aberrations, and misalignments in the spectrometer. We simulated SDR based on this model and found strong agreement with measurements from a vis-OCT system. We verified that SDR altered spectroscopic measurements of fully oxygenated blood. We corrected these alterations by normalizing each spectrally dependent A-line by the measured SDR of the spectrometer. Our investigations of SDR are critical for informing OCT spectrometer design, alignment, and spectroscopic measurements.

Original language	English (US)
Pages (from-to)	2680-2683
Number of pages	4
Journal	Optics Letters
Volume	45
Issue number	9
DOIs	https://doi.org/10.1364/OL.389240
State	Published - May 1 2020

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics

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title = "Spectrally dependent roll-off in visible-light optical coherence tomography",

abstract = "Recent development of visible-light optical coherence tomography (vis-OCT) has introduced new applications for noninvasive spectroscopic imaging. However, the measured spectra may be altered by spectrally dependent roll-off (SDR). We formulated a mathematical model for SDR that accounted for nonuniform wavenumber spacing, optical aberrations, and misalignments in the spectrometer. We simulated SDR based on this model and found strong agreement with measurements from a vis-OCT system. We verified that SDR altered spectroscopic measurements of fully oxygenated blood. We corrected these alterations by normalizing each spectrally dependent A-line by the measured SDR of the spectrometer. Our investigations of SDR are critical for informing OCT spectrometer design, alignment, and spectroscopic measurements.",

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AU - Rubinoff, Ian

AU - Soetikno, Brian

AU - Miller, David A.

AU - Rischall, Isabella

AU - Fawzi, Amani

AU - Kuranov, Roman

AU - Zhang, Hao F.

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AB - Recent development of visible-light optical coherence tomography (vis-OCT) has introduced new applications for noninvasive spectroscopic imaging. However, the measured spectra may be altered by spectrally dependent roll-off (SDR). We formulated a mathematical model for SDR that accounted for nonuniform wavenumber spacing, optical aberrations, and misalignments in the spectrometer. We simulated SDR based on this model and found strong agreement with measurements from a vis-OCT system. We verified that SDR altered spectroscopic measurements of fully oxygenated blood. We corrected these alterations by normalizing each spectrally dependent A-line by the measured SDR of the spectrometer. Our investigations of SDR are critical for informing OCT spectrometer design, alignment, and spectroscopic measurements.

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Spectrally dependent roll-off in visible-light optical coherence tomography

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