Spelling Out CICs: A Multi-Organ Examination of the Contributions of Cancer Initiating Cells’ Role in Tumor Progression

Shivani Baisiwala; Shreya Budhiraja; Chirag Goel; Khizar R. Nandoliya; Miranda R. Saathoff; Atique U. Ahmed

doi:10.1007/s12015-021-10195-x

Spelling Out CICs: A Multi-Organ Examination of the Contributions of Cancer Initiating Cells’ Role in Tumor Progression

Shivani Baisiwala, Shreya Budhiraja, Chirag Goel, Khizar R. Nandoliya, Miranda R. Saathoff, Atique U. Ahmed^*

^*Corresponding author for this work

Neurological Surgery

Research output: Contribution to journal › Review article › peer-review

Abstract

Tumor invasion and metastasis remain the leading causes of mortality for patients with cancer despite current treatment strategies. In some cancer types, recurrence is considered inevitable due to the lack of effective anti-metastatic therapies. Recent studies across many cancer types demonstrate a close relationship between cancer-initiating cells (CICs) and metastasis, as well as general cancer progression. First, this review describes CICs’ contribution to cancer progression. Then we discuss our recent understanding of mechanisms through which CICs promote tumor invasion and metastasis by examining the role of CICs in each stage. Finally, we examine the current understanding of CICs’ contribution to therapeutic resistance and recent developments in CIC-targeting drugs. We believe this understanding is key to advancing anti-CIC clinical therapeutics. Graphical Abstract: [Figure not available: see fulltext.]

Original language	English (US)
Pages (from-to)	228-240
Number of pages	13
Journal	Stem Cell Reviews and Reports
Volume	18
Issue number	1
DOIs	https://doi.org/10.1007/s12015-021-10195-x
State	Published - Jan 2022

Keywords

Cancer stem cell
Invasion
Metastasis
Progression
Stem cell
Therapeutic resistance
Therapeutics

ASJC Scopus subject areas

Cell Biology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s12015-021-10195-x

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title = "Spelling Out CICs: A Multi-Organ Examination of the Contributions of Cancer Initiating Cells{\textquoteright} Role in Tumor Progression",

abstract = "Tumor invasion and metastasis remain the leading causes of mortality for patients with cancer despite current treatment strategies. In some cancer types, recurrence is considered inevitable due to the lack of effective anti-metastatic therapies. Recent studies across many cancer types demonstrate a close relationship between cancer-initiating cells (CICs) and metastasis, as well as general cancer progression. First, this review describes CICs{\textquoteright} contribution to cancer progression. Then we discuss our recent understanding of mechanisms through which CICs promote tumor invasion and metastasis by examining the role of CICs in each stage. Finally, we examine the current understanding of CICs{\textquoteright} contribution to therapeutic resistance and recent developments in CIC-targeting drugs. We believe this understanding is key to advancing anti-CIC clinical therapeutics. Graphical Abstract: [Figure not available: see fulltext.]",

keywords = "Cancer stem cell, Invasion, Metastasis, Progression, Stem cell, Therapeutic resistance, Therapeutics",

author = "Shivani Baisiwala and Shreya Budhiraja and Chirag Goel and Nandoliya, {Khizar R.} and Saathoff, {Miranda R.} and Ahmed, {Atique U.}",

note = "Funding Information: This work was supported by the National Institute of Neurological Disorders and Stroke grant 1R01NS096376, 1R01NS112856 the American Cancer Society grant RSG-16-034-01-DDC (to A.U.A.) and P50CA221747 SPORE for Translational Approaches to Brain Cancer. Publisher Copyright: {\textcopyright} 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.",

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doi = "10.1007/s12015-021-10195-x",

language = "English (US)",

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AU - Goel, Chirag

AU - Nandoliya, Khizar R.

AU - Saathoff, Miranda R.

AU - Ahmed, Atique U.

N1 - Funding Information: This work was supported by the National Institute of Neurological Disorders and Stroke grant 1R01NS096376, 1R01NS112856 the American Cancer Society grant RSG-16-034-01-DDC (to A.U.A.) and P50CA221747 SPORE for Translational Approaches to Brain Cancer. Publisher Copyright: © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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N2 - Tumor invasion and metastasis remain the leading causes of mortality for patients with cancer despite current treatment strategies. In some cancer types, recurrence is considered inevitable due to the lack of effective anti-metastatic therapies. Recent studies across many cancer types demonstrate a close relationship between cancer-initiating cells (CICs) and metastasis, as well as general cancer progression. First, this review describes CICs’ contribution to cancer progression. Then we discuss our recent understanding of mechanisms through which CICs promote tumor invasion and metastasis by examining the role of CICs in each stage. Finally, we examine the current understanding of CICs’ contribution to therapeutic resistance and recent developments in CIC-targeting drugs. We believe this understanding is key to advancing anti-CIC clinical therapeutics. Graphical Abstract: [Figure not available: see fulltext.]

AB - Tumor invasion and metastasis remain the leading causes of mortality for patients with cancer despite current treatment strategies. In some cancer types, recurrence is considered inevitable due to the lack of effective anti-metastatic therapies. Recent studies across many cancer types demonstrate a close relationship between cancer-initiating cells (CICs) and metastasis, as well as general cancer progression. First, this review describes CICs’ contribution to cancer progression. Then we discuss our recent understanding of mechanisms through which CICs promote tumor invasion and metastasis by examining the role of CICs in each stage. Finally, we examine the current understanding of CICs’ contribution to therapeutic resistance and recent developments in CIC-targeting drugs. We believe this understanding is key to advancing anti-CIC clinical therapeutics. Graphical Abstract: [Figure not available: see fulltext.]

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Spelling Out CICs: A Multi-Organ Examination of the Contributions of Cancer Initiating Cells’ Role in Tumor Progression

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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