Spermatogenesis: Overview

Erwin Goldberg, Barry R. Zirkin

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Spermatogenesis is the process in which male gametes are produced in the testis, the male gonad. An exquisitely ordered program of cellular differentiation is put in play to produce spermatozoa, the male germ cells. A diploid population of germline stem cells propagate and differentiate to give rise to haploid flagellated spermatozoa. Stem cells divide and differentiate so that chromosome numbers in the cell nucleus are halved by meiosis and the cell body is re-shaped for motility and ability to penetrate (i.e., fertilize) an ovum, the female gamete. Spermatogenesis occurs in a wave-like fashion, sequestered by a blood-testis barrier from somatic cells, under precise hormonal regulation, resulting in the production of millions of spermatozoa per day. Spermatogenesis is associated with the onset of puberty and is continuous throughout the life of the male.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Reproduction
Number of pages6
ISBN (Electronic)9780128151457
StatePublished - Jan 1 2018


  • Adluminal
  • Chiasmata
  • Ectodermal
  • Haploid spermatids
  • Leydig cells
  • Seminiferous epithelium
  • Sertoli-Sertoli

ASJC Scopus subject areas

  • Medicine(all)


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