Spherical nucleic acids

Joshua I. Cutler, Evelyn Auyeung, Chad A. Mirkin*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

623 Scopus citations


A historical perspective of the development of spherical nucleic acid (SNA) conjugates and other three-dimensional nucleic acid nanostructures is provided. This Perspective details the synthetic methods for preparing them, followed by a discussion of their unique properties and theoretical and experimental models for understanding them. Important examples of technological advances made possible by their fundamental properties spanning the fields of chemistry, molecular diagnostics, gene regulation, medicine, and materials science are also presented.

Original languageEnglish (US)
Pages (from-to)1376-1391
Number of pages16
JournalJournal of the American Chemical Society
Issue number3
StatePublished - Jan 25 2012

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry


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