Spinal cord neurosarcoidosis

Mimi Sohn, Daniel A. Culver, Marc A. Judson, Thomas F. Scott, Jinny Tavee, Kenkichi Nozaki*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


BACKGROUND: Spinal cord neurosarcoidosis (SN) is problematic to diagnose because it mimics other inflammatory neurologic diseases. The authors report the clinical features of 29 SN cases. METHODS: They retrospectively reviewed the medical records of 29 histologically proven sarcoidosis patients with spinal cord involvement seen at 3 university medical centers. They collected clinical data including laboratory and radiological findings. Clinical outcomes were assessed retrospectively using the modified Rankin scale. RESULTS: The cohort included high number of African Americans (16/29, 55%). The lung and intrathoracic lymph nodes were the most common confirmatory biopsy sites (18/29, 62%), whereas the spinal cord was a relatively uncommon one (4/29, 14%). The most common presenting symptoms were lower extremity weakness and paresthesias. Thoracic segment was most frequently involved (21/27, 78%). Lesions were mostly intramedullary (22/27, 81%), although nearly half involved the leptomeninges (13/27, 48%). The average size of a lesion spanned 3.9 spine segments (range, 1-9); 17 of 22 (77%) intramedullary patients had ≥3 spine segments involved. Angiotensin-converting enzyme levels in cerebrospinal fluid were elevated in only 2 of 11 (18%) patients. All patients received glucocorticosteroids. Additional immune-modulating agents were used in 24 of 29 (83%) patients. Scores on the modified Rankin scale at the final follow-up visit were improved. CONCLUSIONS: Most SN cases were diagnosed indirectly based on extraneural tissue biopsy. Extended spinal cord lesion (≥3 spine segments) may be useful to distinguish SN from multiple sclerosis. Cerebrospinal fluid analysis was of limited value. Most patients experienced clinical improvement with immunosuppressive treatment, but many required combination therapy.

Original languageEnglish (US)
Pages (from-to)195-198
Number of pages4
JournalAmerican Journal of the Medical Sciences
Issue number3
StatePublished - Mar 2014


  • Cerebral spinal fluid
  • Immunosuppresive treatment
  • Magnetic resonance imaging
  • Neurosarcoidosis
  • Spinal cord

ASJC Scopus subject areas

  • Medicine(all)


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