Spindle cell carcinoma arising in chronic osteomyelitis; A case report and re-assessment of the literature

James A Hill, H. A. Battifora, J. W. Milgram

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The occurrence of squamous cell carcinoma in long-standing draining sinuses of chronic osteomyelitis is well known. Its incidence has been reported to be 0.23% and 0.5% in two series respectively. In addition, there are in the literature several single case reports of the development of sarcomas in chronic draining sinuses of osteomyelitis. Among them have been angiosarcoma, rhabdomyosarcoma, 'granulation tissue sarcoma', reticulum-cell sarcoma, and most commonly, fibrsarcoma. Although rare, fibrosarcoma has been reported associated with chronically draining osteomyelitis on 7 occasions in the English literature. The authors report here a case of tumour formation in a patient with chronic osteomyelitis that appeared at first to be a sarcoma by routine histological examination but was demonstrated to be a carcinoma by electron microscopy. Further histological sections from the amputation specimen confirmed this diagnosis.

Original languageEnglish (US)
Pages (from-to)187-195
Number of pages9
JournalBulletin of the Hospital for Joint Diseases Orthopaedic Institute
Volume39
Issue number2
StatePublished - Dec 1 1978

ASJC Scopus subject areas

  • Medicine(all)

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