Spindle cell rhabdomyosarcoma of the tongue in an infant: A case report with emphasis on differential diagnosis of childhood spindle cell lesions

Anita Gupta, John Maddalozzo, Thanda Win Htin, Anil Shah, Pauline M Chou*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Malignant tumors are extremely uncommon in infants, specifically in the head and neck region. We present a three-day-old infant with a large, polypoid, soft tissue mass arising from the floor of the mouth. Histologically, this neoplasm consisted of hypercellular and myxoid areas. A mixture of poorly oriented, small, undifferentiated, hyperchromatic, and round to elongate spindle cells was seen. A high degree of striated muscle differentiation was present, along with areas marked by a herringbone pattern, as well as hemangiopericytic vessels and rare mitosis. Immunohistochemical examinations revealed strong nuclear staining for myogenin and diffuse cytoplasmic staining for desmin and muscle-specific actin (HHF-35). The tumor did not stain for S-100. Based on histologic results and immunostains, this lesion was diagnosed as spindle cell rhabdomyosarcoma. This type of lesion involving the tongue is rarely seen in females, neither in association with a herringbone pattern nor with hemangiopericytic vessels. Furthermore, rare benign and malignant spindle lesions, such as cellular fibromatosis, fetal rhabdomyoma, infantile hemangiopericytoma, infantile rhabdomyofibrosarcoma, and infantile fibrosarcoma, should be in the differential diagnosis and excluded.

Original languageEnglish (US)
Pages (from-to)537-543
Number of pages7
JournalPathology Research and Practice
Volume200
Issue number7-8
DOIs
StatePublished - Jan 1 2004

Keywords

  • Childhood tumors
  • Rhabdomyofibrosarcoma
  • Rhabdomyosarcoma
  • Spindle cell lesions
  • Tongue

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cell Biology

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