Splanchnic factors enhance the norepinephrine response to oral glucose in aged man

Richard P. Tonino; Kenneth L. Minaker; James B. Young; Lewis Landsberg; John W. Rowe

doi:10.1016/0531-5565(86)90046-X

Splanchnic factors enhance the norepinephrine response to oral glucose in aged man

Richard P. Tonino, Kenneth L. Minaker, James B. Young, Lewis Landsberg, John W. Rowe^*

^*Corresponding author for this work

Medicine, Endocrinology Division

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Oral glucose has been shown to increase sympathetic nervous system (SNS) activity more in old than in young subjects. In contrast intravenous glucose during euglycemic hyperinsulinemia increases SNS activity in young but not in old subjects. To evaluate the role of splanchnic factors in this discrepancy, we employed a modification of the glucose clamp technique in 6 young (24-39 years) and 8 old (65-83 years) normal males. Each subject underwent two studies in which insulin was infused at 120mU/m² · min for 3 h and either oral glucose (50 gms) or water was given 60 min after initiating insulin. Euglycemia was maintained in all studies. When compared to control drink, oral glucose elevated norepinephrine in old (p < 0.01), but not in young subjects. The difference between old and young was significant (p < 0.02). When compared to control drink, oral glucose increased pulse rate and double product in the young, and pulse rate in the old. These results indicate that oral glucose activates the SNS in the elderly via splanchnic mechanisms independent of changes in circulating levels of glucose or insulin.

Original language	English (US)
Pages (from-to)	413-422
Number of pages	10
Journal	Experimental Gerontology
Volume	21
Issue number	4-5
DOIs	https://doi.org/10.1016/0531-5565(86)90046-X
State	Published - 1986

Funding

Acknowledgments--The authors express appreciation to Gall Wong, Susan Gunn, and the nursing and dietary staffs of the Clinical Research Center of the Beth Israel Hospital for assistance in these studies, This work was supported by General Clinical Research Center grant RR01032 and the National Institutes of Health grants AG00599, AM28082, AM20378 and HL24084. Dr. Minaker is the recipient of the Greenwall Foundation Award of the American Federation for Aging Research. Dr. Rowe is a recipient of an award from the MacArthur Foundation.

Keywords

carbohydrate ingestion
cardiovascular response
catecholamines
glucose clamp

ASJC Scopus subject areas

Genetics
Endocrinology
Aging
Molecular Biology
Biochemistry
Cell Biology

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10.1016/0531-5565(86)90046-X

Cite this

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title = "Splanchnic factors enhance the norepinephrine response to oral glucose in aged man",

abstract = "Oral glucose has been shown to increase sympathetic nervous system (SNS) activity more in old than in young subjects. In contrast intravenous glucose during euglycemic hyperinsulinemia increases SNS activity in young but not in old subjects. To evaluate the role of splanchnic factors in this discrepancy, we employed a modification of the glucose clamp technique in 6 young (24-39 years) and 8 old (65-83 years) normal males. Each subject underwent two studies in which insulin was infused at 120mU/m2 · min for 3 h and either oral glucose (50 gms) or water was given 60 min after initiating insulin. Euglycemia was maintained in all studies. When compared to control drink, oral glucose elevated norepinephrine in old (p < 0.01), but not in young subjects. The difference between old and young was significant (p < 0.02). When compared to control drink, oral glucose increased pulse rate and double product in the young, and pulse rate in the old. These results indicate that oral glucose activates the SNS in the elderly via splanchnic mechanisms independent of changes in circulating levels of glucose or insulin.",

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author = "Tonino, {Richard P.} and Minaker, {Kenneth L.} and Young, {James B.} and Lewis Landsberg and Rowe, {John W.}",

note = "Funding Information: Acknowledgments--The authors express appreciation to Gall Wong, Susan Gunn, and the nursing and dietary staffs of the Clinical Research Center of the Beth Israel Hospital for assistance in these studies, This work was supported by General Clinical Research Center grant RR01032 and the National Institutes of Health grants AG00599, AM28082, AM20378 and HL24084. Dr. Minaker is the recipient of the Greenwall Foundation Award of the American Federation for Aging Research. Dr. Rowe is a recipient of an award from the MacArthur Foundation.",

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AU - Rowe, John W.

N1 - Funding Information: Acknowledgments--The authors express appreciation to Gall Wong, Susan Gunn, and the nursing and dietary staffs of the Clinical Research Center of the Beth Israel Hospital for assistance in these studies, This work was supported by General Clinical Research Center grant RR01032 and the National Institutes of Health grants AG00599, AM28082, AM20378 and HL24084. Dr. Minaker is the recipient of the Greenwall Foundation Award of the American Federation for Aging Research. Dr. Rowe is a recipient of an award from the MacArthur Foundation.

PY - 1986

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N2 - Oral glucose has been shown to increase sympathetic nervous system (SNS) activity more in old than in young subjects. In contrast intravenous glucose during euglycemic hyperinsulinemia increases SNS activity in young but not in old subjects. To evaluate the role of splanchnic factors in this discrepancy, we employed a modification of the glucose clamp technique in 6 young (24-39 years) and 8 old (65-83 years) normal males. Each subject underwent two studies in which insulin was infused at 120mU/m2 · min for 3 h and either oral glucose (50 gms) or water was given 60 min after initiating insulin. Euglycemia was maintained in all studies. When compared to control drink, oral glucose elevated norepinephrine in old (p < 0.01), but not in young subjects. The difference between old and young was significant (p < 0.02). When compared to control drink, oral glucose increased pulse rate and double product in the young, and pulse rate in the old. These results indicate that oral glucose activates the SNS in the elderly via splanchnic mechanisms independent of changes in circulating levels of glucose or insulin.

AB - Oral glucose has been shown to increase sympathetic nervous system (SNS) activity more in old than in young subjects. In contrast intravenous glucose during euglycemic hyperinsulinemia increases SNS activity in young but not in old subjects. To evaluate the role of splanchnic factors in this discrepancy, we employed a modification of the glucose clamp technique in 6 young (24-39 years) and 8 old (65-83 years) normal males. Each subject underwent two studies in which insulin was infused at 120mU/m2 · min for 3 h and either oral glucose (50 gms) or water was given 60 min after initiating insulin. Euglycemia was maintained in all studies. When compared to control drink, oral glucose elevated norepinephrine in old (p < 0.01), but not in young subjects. The difference between old and young was significant (p < 0.02). When compared to control drink, oral glucose increased pulse rate and double product in the young, and pulse rate in the old. These results indicate that oral glucose activates the SNS in the elderly via splanchnic mechanisms independent of changes in circulating levels of glucose or insulin.

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Splanchnic factors enhance the norepinephrine response to oral glucose in aged man

Abstract

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Keywords

ASJC Scopus subject areas

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