Splenic rupture in a patient with plasma cell myeloma following G-CSF/ GM-CSF administration for stem cell transplantation and review of the literature

R. Veerappan, M. Morrison, S. Williams, D. Variakojis*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations

Abstract

Recipients of granulocyte-colony stimulating factor/granulocyte macrophage-colony stimulating factor are not only individuals with underlying disorders, but also healthy donors undergoing peripheral blood progenitor cell (PBPC) mobilization. In addition to the known adverse effects associated with G-CSF, complications such as splenic rupture have also been reported. A review of the English literature, with addition of a patient with plasma cell myeloma, reveals that splenic rupture occurs not only in patients with underlying disease, but also in healthy PBPC donors. Although the cause of splenic rupture does not appear to be associated with any specific condition, physicians should be alerted to the possibility of this potentially fatal complication in individuals receiving G-CSF therapy.

Original languageEnglish (US)
Pages (from-to)361-364
Number of pages4
JournalBone Marrow Transplantation
Volume40
Issue number4
DOIs
StatePublished - Aug 2 2007

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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