Spontaneous fluctuations in oxygen tension in the cat retina

Rod D. Braun, Robert A. Linsenmeier*, Charles M. Yancey

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Oxygen tension was recorded with double-barreled microelectrodes in the retina of anesthetized cats and monkeys. The oxygen tension (PO2) was often observed to undergo spontaneous irregular fluctuations with peak-to-peak amplitudes of about 3 to as much as 20 mm Hg. These fluctuations were observed only in the vascularized inner 40 to 50% of the retina, not in the avascular outer retina, and they were not correlated with the voltage recorded by the second barrel of the microelectrode. Oxygen records from the cat retina were subjected to Fourier analysis to determine their frequency content. The peak frequency was usually in the range of 3.5 to 10.5 c/min (0.06 to 0.18 Hz), considerably below the respiratory frequency of 20 to 30 c/min or the heart rate of 180 to 240 c/min. The power of the oxygen fluctuations fell gradually to less than 10% of the peak power by 60 c/min. It is suggested, based on the depth distribution and on comparison of these data with the literature on vasomotion, that the PO2 fluctuations are the result of changes in oxygen supply caused by normal fluctuations of arteriolar diameter (vasomotion) and/or capillary perfusion.

Original languageEnglish (US)
Pages (from-to)73-84
Number of pages12
JournalMicrovascular Research
Volume44
Issue number1
DOIs
StatePublished - Jul 1992

ASJC Scopus subject areas

  • Biochemistry
  • Cardiology and Cardiovascular Medicine
  • Cell Biology

Fingerprint Dive into the research topics of 'Spontaneous fluctuations in oxygen tension in the cat retina'. Together they form a unique fingerprint.

Cite this