Spontaneous T cell proliferation: A physiologic process to create and maintain homeostatic balance and diversity of the immune system

Booki Min*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

Naive T lymphocytes undergo heterogeneous proliferative responses when introduced into lymphopenic hosts, referred to as "homeostatic proliferation" and "spontaneous proliferation." Spontaneous proliferation is a unique process through which the immune system generates memory phenotype cells with increasing T cell receptors repertoire complexity. Here, the mechanisms that initiate and control spontaneous proliferation are discussed.

Original languageEnglish (US)
Article number547
JournalFrontiers in immunology
Volume9
Issue numberMAR
DOIs
StatePublished - Mar 19 2018
Externally publishedYes

Keywords

  • Homeostasis
  • Lymphocytes
  • Lymphopenia
  • Proliferation
  • T cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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