SSRIs, adolescents, and aggression

Tempering human implications regarding SSRI-induced aggression in hamsters: Comment on ricci and melloni (2012)

David H. Rubin, John T. Walkup*

*Corresponding author for this work

Research output: Contribution to journalComment/debate

1 Citation (Scopus)

Abstract

The safety and efficacy of selective serotonin reuptake inhibitors (SSRIs) in adolescents is a topic of great import, complexity, and controversy. Conflicting evidence derived from clinical trials, translational research, and basic science demands that investigators in the field use critical thinking in the synthesis of evidence from varying sources. The new study by Ricci and Melloni presented in the current issue of this journal shows that exposure to low-dose fluoxetine during adolescence predisposes Syrian hamsters to offensive aggression, with demonstrable neurophysiologic changes. This work adds to the understanding of the mammalian neuropathways of aggression, but is limited in its direct generalizability to human adolescent clinical populations.

Original languageEnglish (US)
Pages (from-to)742-747
Number of pages6
JournalBehavioral Neuroscience
Volume126
Issue number5
DOIs
StatePublished - Oct 1 2012

Fingerprint

Serotonin Uptake Inhibitors
Aggression
Cricetinae
Translational Medical Research
Fluoxetine
Mesocricetus
Research Personnel
Clinical Trials
Safety
Population

Keywords

  • Adolescents
  • Aggression
  • Depression
  • Hamsters
  • SSRIs

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

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abstract = "The safety and efficacy of selective serotonin reuptake inhibitors (SSRIs) in adolescents is a topic of great import, complexity, and controversy. Conflicting evidence derived from clinical trials, translational research, and basic science demands that investigators in the field use critical thinking in the synthesis of evidence from varying sources. The new study by Ricci and Melloni presented in the current issue of this journal shows that exposure to low-dose fluoxetine during adolescence predisposes Syrian hamsters to offensive aggression, with demonstrable neurophysiologic changes. This work adds to the understanding of the mammalian neuropathways of aggression, but is limited in its direct generalizability to human adolescent clinical populations.",
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