Stabilization of exosome-targeting peptides via engineered glycosylation

Michelle E. Hung; Joshua N. Leonard

doi:10.1074/jbc.M114.621383

Stabilization of exosome-targeting peptides via engineered glycosylation

Michelle E. Hung, Joshua N. Leonard^*

^*Corresponding author for this work

Chemical and Biological Engineering

Research output: Contribution to journal › Article › peer-review

263 Scopus citations

Abstract

Background: Exosomes show great promise as targeted therapeutic delivery vehicles. Results: A strategy was identified for stabilizing targeting peptides on the surface of exosomes. Conclusion: Glycosylation protects targeting ligands displayed on the surface of exosomes from proteolytic degradation. Significance: Strategies for robust display of targeting peptides will enable targeted delivery of therapeutic exosomes.

Original language	English (US)
Pages (from-to)	8166-8172
Number of pages	7
Journal	Journal of Biological Chemistry
Volume	290
Issue number	13
DOIs	https://doi.org/10.1074/jbc.M114.621383
State	Published - Mar 27 2015

Funding

ASJC Scopus subject areas

Molecular Biology
Biochemistry
Cell Biology

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10.1074/jbc.M114.621383

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title = "Stabilization of exosome-targeting peptides via engineered glycosylation",

abstract = "Background: Exosomes show great promise as targeted therapeutic delivery vehicles. Results: A strategy was identified for stabilizing targeting peptides on the surface of exosomes. Conclusion: Glycosylation protects targeting ligands displayed on the surface of exosomes from proteolytic degradation. Significance: Strategies for robust display of targeting peptides will enable targeted delivery of therapeutic exosomes.",

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AU - Leonard, Joshua N.

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AB - Background: Exosomes show great promise as targeted therapeutic delivery vehicles. Results: A strategy was identified for stabilizing targeting peptides on the surface of exosomes. Conclusion: Glycosylation protects targeting ligands displayed on the surface of exosomes from proteolytic degradation. Significance: Strategies for robust display of targeting peptides will enable targeted delivery of therapeutic exosomes.

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Stabilization of exosome-targeting peptides via engineered glycosylation

Abstract

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ASJC Scopus subject areas

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