Stabilization of exosome-targeting peptides via engineered glycosylation

Michelle E. Hung, Joshua N. Leonard*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

110 Scopus citations

Abstract

Background: Exosomes show great promise as targeted therapeutic delivery vehicles. Results: A strategy was identified for stabilizing targeting peptides on the surface of exosomes. Conclusion: Glycosylation protects targeting ligands displayed on the surface of exosomes from proteolytic degradation. Significance: Strategies for robust display of targeting peptides will enable targeted delivery of therapeutic exosomes.

Original languageEnglish (US)
Pages (from-to)8166-8172
Number of pages7
JournalJournal of Biological Chemistry
Volume290
Issue number13
DOIs
StatePublished - Mar 27 2015

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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