@article{9a4e9104b8f54a69a2940acfcf46e4e6,
title = "Stabilization of Formate Dehydrogenase in a Metal–Organic Framework for Bioelectrocatalytic Reduction of CO2",
abstract = "The efficient fixation of excess CO2 from the atmosphere to yield value-added chemicals remains crucial in response to the increasing levels of carbon emission. Coupling enzymatic reactions with electrochemical regeneration of cofactors is a promising technique for fixing CO2, while producing biomass which can be further transformed into biofuels. Herein, a bioelectrocatalytic system was established by depositing crystallites of a mesoporous metal–organic framework (MOF), termed NU-1006, containing formate dehydrogenase, on a fluorine-doped tin oxide glass electrode modified with Cp*Rh(2,2′-bipyridyl-5,5′-dicarboxylic acid)Cl2 complex. This system converts CO2 into formic acid at a rate of 79±3.4 mm h−1 with electrochemical regeneration of the nicotinamide adenine dinucleotide cofactor. The MOF–enzyme composite exhibited significantly higher catalyst stability when subjected to non-native conditions compared to the free enzyme, doubling the formic acid yield.",
keywords = "bioelectrocatalysis, carbon dioxide fixation, formate dehydrogenase stabilization, mesoporous material",
author = "Yijing Chen and Peng Li and Hyunho Noh and Kung, {Chung Wei} and Buru, {Cassandra T.} and Xingjie Wang and Xuan Zhang and Farha, {Omar K.}",
note = "Funding Information: This work was supported as part of the Center for Light Energy Activated Redox Processes (LEAP), an Energy Frontier Research Center funded by the U.S. Department of Energy, Office of Science, Basic Energy Sciences under Award number DE-SC0001059. H.N. gratefully acknowledges support from the Ryan Fellowship program of the North-western University International Institute of Nanotechnology. This work made use of the EPIC facility of Northwestern University≫s NUANCE Center, which has received support from the Soft and Hybrid Nanotechnology Experimental (SHyNE) Resource (NSF NNCI-1542205); the MRSEC program (NSF DMR-1720139) at the Materials Research Center; the International Institute for Nanotechnology (IIN); the Keck Foundation; and the State of Illinois, through the IIN. Metal analysis was performed at the Northwestern University Quantitative Bio-element Imaging Center (QBIC). Publisher Copyright: {\textcopyright} 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",
year = "2019",
month = jun,
day = "3",
doi = "10.1002/anie.201901981",
language = "English (US)",
volume = "58",
pages = "7682--7686",
journal = "Angewandte Chemie - International Edition",
issn = "1433-7851",
publisher = "John Wiley and Sons Ltd",
number = "23",
}