Abstract
Background: Sleep disturbance is among the most frequent and distressing symptoms reported by gynecologic cancer survivors. Existing evidence-based behavioral sleep interventions are limited by implementation burden, which can decrease adherence. Purpose: As part of the preparation phase of the multiphase optimization strategy (MOST), this study solicited stakeholder feedback to maximize adherence in a planned behavioral sleep/circadian intervention optimization trial. Methods: Thirteen post-treatment survivors of early-stage gynecologic cancer completed the protocol for the planned optimization trial, including simultaneous receipt of all candidate intervention components. This included six weeks of combined sleep restriction, stimulus control, and systematic exposure to morning bright light. Participants then completed a semi-structured interview to provide feedback on their experience. We used a rapid analytic approach to quickly identify actionable feedback from de-identified transcripts. Results: Participants generally reacted positively to the intervention components. Actionable feedback identified recommended protocol modifications and was categorized into four overarching themes: (i) remove barriers to engagement; (ii) revise for clarity; (iii) augment content; and (iv) consider individual circumstances. Conclusions: Rapid qualitative analysis enabled us to effectively modify our planned study protocol on an expedited timeline. This approach is consistent with the core principles of MOST and can be incorporated into the Preparation phase to enhance optimization efforts.
| Original language | English (US) |
|---|---|
| Article number | ibaf001 |
| Journal | Translational behavioral medicine |
| Volume | 15 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2025 |
Funding
Conflict of interest statement. JCO is employed by Nox Health and receives salary for work completed in this capacity. SP reports personal fees from Apria Healthcare, Inc., Abbvie Inc., Dynamedex, Inc., Jazz Pharmaceuticals, Inc., and UpToDate, Inc., and research grants from Philips, Inc., Sommetrics, Inc., Regeneron, Inc., and Verily Lifesciences. These do not have any relationship to the contents of this manuscript. The authors have no other relevant financial or nonfinancial interests to disclose. This research was supported by the National Cancer Institute under Grant Numbers K08CA247973 and P30CA023074, the University of Arizona College of Nursing, and the National Institutes of Health\u2019s National Center for Advancing Translational Sciences under Grant Number UL1TR001422. The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; or decision to submit the manuscript for publication. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Keywords
- Multiphase optimization strategy
- gynecologic cancer
- rapid qualitative analysis
- sleep
ASJC Scopus subject areas
- Applied Psychology
- Behavioral Neuroscience
