Standardizing care for acute decompensated heart failure in a large megatrial: The approach for the Acute Studies of Clinical Effectiveness of Nesiritide in Subjects with Decompensated Heart Failure (ASCEND-HF)

Justin A. Ezekowitz; Adrian F. Hernandez; Randall C. Starling; Clyde W. Yancy; Barry Massie; James A. Hill; Henry Krum; Rafael Diaz; Piotr Ponikowski; Marco Metra; Jonathon G. Howlett; Daniel Gennevois; Christopher M. O'Connor; Robert M. Califf; Gregg C. Fonarow

doi:10.1016/j.ahj.2008.10.002

Standardizing care for acute decompensated heart failure in a large megatrial: The approach for the Acute Studies of Clinical Effectiveness of Nesiritide in Subjects with Decompensated Heart Failure (ASCEND-HF)

Justin A. Ezekowitz^*, Adrian F. Hernandez, Randall C. Starling, Clyde W. Yancy, Barry Massie, James A. Hill, Henry Krum, Rafael Diaz, Piotr Ponikowski, Marco Metra, Jonathon G. Howlett, Daniel Gennevois, Christopher M. O'Connor, Robert M. Califf, Gregg C. Fonarow

^*Corresponding author for this work

Medicine, Cardiology Division

Research output: Contribution to journal › Review article › peer-review

26 Scopus citations

Abstract

Acute decompensated heart failure (ADHF) is a major public health issue and remains a heterogeneous, complex, and difficult condition to manage. Although novel acute therapies are being tested in large randomized clinical trials, opportunities exist to improve the standard of care by ensuring optimal adherence to currently established evidence-based interventions for HF. Consideration of the goals of therapy and practical application of current methods to assess for clinical improvement may lead to improved patient management and possibly improved outcomes for patients with ADHF. This review provides key practical information regarding the current standard of care for patients with ADHF including the goals of therapy, management of acute and chronic medications, and discharge/transition of care planning.

Original language	English (US)
Pages (from-to)	219-228
Number of pages	10
Journal	American heart journal
Volume	157
Issue number	2
DOIs	https://doi.org/10.1016/j.ahj.2008.10.002
State	Published - Feb 2009

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ahj.2008.10.002

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Ezekowitz, J. A., Hernandez, A. F., Starling, R. C., Yancy, C. W., Massie, B., Hill, J. A., Krum, H., Diaz, R., Ponikowski, P., Metra, M., Howlett, J. G., Gennevois, D., O'Connor, C. M., Califf, R. M., & Fonarow, G. C. (2009). Standardizing care for acute decompensated heart failure in a large megatrial: The approach for the Acute Studies of Clinical Effectiveness of Nesiritide in Subjects with Decompensated Heart Failure (ASCEND-HF). American heart journal, 157(2), 219-228. https://doi.org/10.1016/j.ahj.2008.10.002

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title = "Standardizing care for acute decompensated heart failure in a large megatrial: The approach for the Acute Studies of Clinical Effectiveness of Nesiritide in Subjects with Decompensated Heart Failure (ASCEND-HF)",

abstract = "Acute decompensated heart failure (ADHF) is a major public health issue and remains a heterogeneous, complex, and difficult condition to manage. Although novel acute therapies are being tested in large randomized clinical trials, opportunities exist to improve the standard of care by ensuring optimal adherence to currently established evidence-based interventions for HF. Consideration of the goals of therapy and practical application of current methods to assess for clinical improvement may lead to improved patient management and possibly improved outcomes for patients with ADHF. This review provides key practical information regarding the current standard of care for patients with ADHF including the goals of therapy, management of acute and chronic medications, and discharge/transition of care planning.",

author = "Ezekowitz, {Justin A.} and Hernandez, {Adrian F.} and Starling, {Randall C.} and Yancy, {Clyde W.} and Barry Massie and Hill, {James A.} and Henry Krum and Rafael Diaz and Piotr Ponikowski and Marco Metra and Howlett, {Jonathon G.} and Daniel Gennevois and O'Connor, {Christopher M.} and Califf, {Robert M.} and Fonarow, {Gregg C.}",

note = "Funding Information: All of the authors are Steering Committee members of the ASCEND-HF trial, sponsored by Johnson & Johnson Pharmaceuticals. Dr Ezekowitz is supported by the Randomized Controlled Trials program of the Canadian Institutes of Health Research. Dr Fonarow has received research support, consultant fees, and honorarium from Scios/Johnson & Johnson (Mountain View, CA), GlaxoSmithKline (Brentford, UK), and Medtronic (Minneapolis, MN). ",

year = "2009",

month = feb,

doi = "10.1016/j.ahj.2008.10.002",

language = "English (US)",

volume = "157",

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Ezekowitz, JA, Hernandez, AF, Starling, RC, Yancy, CW, Massie, B, Hill, JA, Krum, H, Diaz, R, Ponikowski, P, Metra, M, Howlett, JG, Gennevois, D, O'Connor, CM, Califf, RM & Fonarow, GC 2009, 'Standardizing care for acute decompensated heart failure in a large megatrial: The approach for the Acute Studies of Clinical Effectiveness of Nesiritide in Subjects with Decompensated Heart Failure (ASCEND-HF)', American heart journal, vol. 157, no. 2, pp. 219-228. https://doi.org/10.1016/j.ahj.2008.10.002

Standardizing care for acute decompensated heart failure in a large megatrial : The approach for the Acute Studies of Clinical Effectiveness of Nesiritide in Subjects with Decompensated Heart Failure (ASCEND-HF). / Ezekowitz, Justin A.; Hernandez, Adrian F.; Starling, Randall C. et al.

In: American heart journal, Vol. 157, No. 2, 02.2009, p. 219-228.

Research output: Contribution to journal › Review article › peer-review

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T1 - Standardizing care for acute decompensated heart failure in a large megatrial

T2 - The approach for the Acute Studies of Clinical Effectiveness of Nesiritide in Subjects with Decompensated Heart Failure (ASCEND-HF)

AU - Ezekowitz, Justin A.

AU - Hernandez, Adrian F.

AU - Starling, Randall C.

AU - Yancy, Clyde W.

AU - Massie, Barry

AU - Hill, James A.

AU - Krum, Henry

AU - Diaz, Rafael

AU - Ponikowski, Piotr

AU - Metra, Marco

AU - Howlett, Jonathon G.

AU - Gennevois, Daniel

AU - O'Connor, Christopher M.

AU - Califf, Robert M.

AU - Fonarow, Gregg C.

N1 - Funding Information: All of the authors are Steering Committee members of the ASCEND-HF trial, sponsored by Johnson & Johnson Pharmaceuticals. Dr Ezekowitz is supported by the Randomized Controlled Trials program of the Canadian Institutes of Health Research. Dr Fonarow has received research support, consultant fees, and honorarium from Scios/Johnson & Johnson (Mountain View, CA), GlaxoSmithKline (Brentford, UK), and Medtronic (Minneapolis, MN).

PY - 2009/2

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AB - Acute decompensated heart failure (ADHF) is a major public health issue and remains a heterogeneous, complex, and difficult condition to manage. Although novel acute therapies are being tested in large randomized clinical trials, opportunities exist to improve the standard of care by ensuring optimal adherence to currently established evidence-based interventions for HF. Consideration of the goals of therapy and practical application of current methods to assess for clinical improvement may lead to improved patient management and possibly improved outcomes for patients with ADHF. This review provides key practical information regarding the current standard of care for patients with ADHF including the goals of therapy, management of acute and chronic medications, and discharge/transition of care planning.

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JO - American Heart Journal

JF - American Heart Journal

SN - 0002-8703

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Standardizing care for acute decompensated heart failure in a large megatrial: The approach for the Acute Studies of Clinical Effectiveness of Nesiritide in Subjects with Decompensated Heart Failure (ASCEND-HF)

Abstract

ASJC Scopus subject areas

UN SDGs

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