TY - JOUR
T1 - Standardizing care for acute decompensated heart failure in a large megatrial
T2 - The approach for the Acute Studies of Clinical Effectiveness of Nesiritide in Subjects with Decompensated Heart Failure (ASCEND-HF)
AU - Ezekowitz, Justin A.
AU - Hernandez, Adrian F.
AU - Starling, Randall C.
AU - Yancy, Clyde W.
AU - Massie, Barry
AU - Hill, James A.
AU - Krum, Henry
AU - Diaz, Rafael
AU - Ponikowski, Piotr
AU - Metra, Marco
AU - Howlett, Jonathon G.
AU - Gennevois, Daniel
AU - O'Connor, Christopher M.
AU - Califf, Robert M.
AU - Fonarow, Gregg C.
N1 - Funding Information:
All of the authors are Steering Committee members of the ASCEND-HF trial, sponsored by Johnson & Johnson Pharmaceuticals. Dr Ezekowitz is supported by the Randomized Controlled Trials program of the Canadian Institutes of Health Research. Dr Fonarow has received research support, consultant fees, and honorarium from Scios/Johnson & Johnson (Mountain View, CA), GlaxoSmithKline (Brentford, UK), and Medtronic (Minneapolis, MN).
Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.
PY - 2009/2
Y1 - 2009/2
N2 - Acute decompensated heart failure (ADHF) is a major public health issue and remains a heterogeneous, complex, and difficult condition to manage. Although novel acute therapies are being tested in large randomized clinical trials, opportunities exist to improve the standard of care by ensuring optimal adherence to currently established evidence-based interventions for HF. Consideration of the goals of therapy and practical application of current methods to assess for clinical improvement may lead to improved patient management and possibly improved outcomes for patients with ADHF. This review provides key practical information regarding the current standard of care for patients with ADHF including the goals of therapy, management of acute and chronic medications, and discharge/transition of care planning.
AB - Acute decompensated heart failure (ADHF) is a major public health issue and remains a heterogeneous, complex, and difficult condition to manage. Although novel acute therapies are being tested in large randomized clinical trials, opportunities exist to improve the standard of care by ensuring optimal adherence to currently established evidence-based interventions for HF. Consideration of the goals of therapy and practical application of current methods to assess for clinical improvement may lead to improved patient management and possibly improved outcomes for patients with ADHF. This review provides key practical information regarding the current standard of care for patients with ADHF including the goals of therapy, management of acute and chronic medications, and discharge/transition of care planning.
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U2 - 10.1016/j.ahj.2008.10.002
DO - 10.1016/j.ahj.2008.10.002
M3 - Review article
C2 - 19185628
AN - SCOPUS:58749092123
VL - 157
SP - 219
EP - 228
JO - American Heart Journal
JF - American Heart Journal
SN - 0002-8703
IS - 2
ER -