TY - JOUR
T1 - STAT activation in malignancies
T2 - Roles in tumor progression and in the generation of antineoplastic effects of IFNs
AU - Wang, Ben X.
AU - Platanias, Leonidas C.
AU - Fish, Eleanor N.
PY - 2013/4/1
Y1 - 2013/4/1
N2 - As signal transducers and transcription factors, signal transducer and activator of transcriptions (STATs) exert a critical role in cell growth, differentiation, and cell death. Their dysregulation that may lead to constitutive activation, no activation, or functional change, is associated with many different cancers. In this review, the contribution of STATs to cancer growth and progression is presented, and then the context in which interferon regulation of STAT activation provides a mechanism for therapeutic intervention for specific cancers is discussed.
AB - As signal transducers and transcription factors, signal transducer and activator of transcriptions (STATs) exert a critical role in cell growth, differentiation, and cell death. Their dysregulation that may lead to constitutive activation, no activation, or functional change, is associated with many different cancers. In this review, the contribution of STATs to cancer growth and progression is presented, and then the context in which interferon regulation of STAT activation provides a mechanism for therapeutic intervention for specific cancers is discussed.
UR - http://www.scopus.com/inward/record.url?scp=84876155664&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84876155664&partnerID=8YFLogxK
U2 - 10.1089/jir.2012.0154
DO - 10.1089/jir.2012.0154
M3 - Review article
C2 - 23570384
AN - SCOPUS:84876155664
SN - 1079-9907
VL - 33
SP - 181
EP - 188
JO - Journal of Interferon and Cytokine Research
JF - Journal of Interferon and Cytokine Research
IS - 4
ER -
