Stat3 activation is required for cellular transformation by v-src

Jacqueline F. Bromberg, Curt M. Horvath, Daniel Besser, Wyndham W. Lathem, James E. Darnell*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

560 Scopus citations

Abstract

Stat3 activation has been associated with cytokine-induced proliferation, anti-apoptosis, and transformation. Constitutively activated Stat3 has been found in many human tumors as well as v-abl- and v-src- transformed cell lines. Because of these correlations, we examined directly the relationship of activated Stat3 to cellular transformation and found that wild-type Stat3 enhances the transforming potential of v-src while three dominant negative Stat3 mutants inhibit v-src transformation. Stat3 wild- type or mutant proteins did not affect v-ras transformation. We conclude that Stat3 has a necessary role in v-src transformation.

Original languageEnglish (US)
Pages (from-to)2553-2558
Number of pages6
JournalMolecular and cellular biology
Volume18
Issue number5
DOIs
StatePublished - May 1998

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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