TY - JOUR
T1 - State dependence of noise correlations in macaque primary visual cortex
AU - Ecker, Alexander S.
AU - Berens, Philipp
AU - Cotton, R. James
AU - Subramaniyan, Manivannan
AU - Denfield, George H.
AU - Cadwell, Cathryn R.
AU - Smirnakis, Stelios M.
AU - Bethge, Matthias
AU - Tolias, Andreas S.
N1 - Funding Information:
This work was supported by grants NEI R01-EY018847, NEI P30-EY002520-33, and the NIH-Pioneer award DP1-OD008301 to A.S.T.; the McKnight Scholar Award to A.S.T; the Bernstein Center for Computational Neuroscience (FKZ 01GQ1002); the German Excellency Initiative through the Centre for Integrative Neuroscience Tübingen (EXC307); an HHMI Early Career Award to S.S.; and NEI R01-EY019272 to S.S.
PY - 2014/4/2
Y1 - 2014/4/2
N2 - Shared, trial-to-trial variability in neuronal populations has a strong impact on the accuracy of information processing in the brain. Estimates of the level of such noise correlations are diverse, ranging from 0.01 to 0.4, with little consensus on which factors account for these differences. Here we addressed one important factor that varied across studies, asking how anesthesia affects the population activity structure in macaque primary visual cortex. We found that under opioid anesthesia, activity was dominated by strong coordinated fluctuations on a timescale of 1-2 Hz, which were mostly absent in awake, fixating monkeys. Accounting for these global fluctuations markedly reduced correlations under anesthesia, matching those observed during wakefulness and reconciling earlier studies conducted under anesthesia and in awake animals. Our results show that internal signals, such as brain state transitions under anesthesia, can induce noise correlations but can also be estimated and accounted for based on neuronal population activity.
AB - Shared, trial-to-trial variability in neuronal populations has a strong impact on the accuracy of information processing in the brain. Estimates of the level of such noise correlations are diverse, ranging from 0.01 to 0.4, with little consensus on which factors account for these differences. Here we addressed one important factor that varied across studies, asking how anesthesia affects the population activity structure in macaque primary visual cortex. We found that under opioid anesthesia, activity was dominated by strong coordinated fluctuations on a timescale of 1-2 Hz, which were mostly absent in awake, fixating monkeys. Accounting for these global fluctuations markedly reduced correlations under anesthesia, matching those observed during wakefulness and reconciling earlier studies conducted under anesthesia and in awake animals. Our results show that internal signals, such as brain state transitions under anesthesia, can induce noise correlations but can also be estimated and accounted for based on neuronal population activity.
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U2 - 10.1016/j.neuron.2014.02.006
DO - 10.1016/j.neuron.2014.02.006
M3 - Article
C2 - 24698278
AN - SCOPUS:84897427371
VL - 82
SP - 235
EP - 248
JO - Neuron
JF - Neuron
SN - 0896-6273
IS - 1
ER -