State of Sweat: Emerging Wearable Systems for Real-Time, Noninvasive Sweat Sensing and Analytics

Roozbeh Ghaffari; Da Som Yang; Joohee Kim; Amer Mansour; John A. Wright; Jeffrey B. Model; Donald E. Wright; John A. Rogers; Tyler R. Ray

doi:10.1021/acssensors.1c01133

State of Sweat: Emerging Wearable Systems for Real-Time, Noninvasive Sweat Sensing and Analytics

Roozbeh Ghaffari, Da Som Yang, Joohee Kim, Amer Mansour, John A. Wright, Jeffrey B. Model, Donald E. Wright, John A. Rogers, Tyler R. Ray^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

32 Scopus citations

Abstract

Skin-interfaced wearable systems with integrated colorimetric assays, microfluidic channels, and electrochemical sensors offer powerful capabilities for noninvasive, real-time sweat analysis. This Perspective details recent progress in the development and translation of novel wearable sensors for personalized assessment of sweat dynamics and biomarkers, with precise sampling and real-time analysis. Sensor accuracy, system ruggedness, and large-scale deployment in remote environments represent key opportunity areas, enabling broad deployment in the context of field studies, clinical trials, and recent commercialization. On-body measurements in these contexts show good agreement compared to conventional laboratory-based sweat analysis approaches. These device demonstrations highlight the utility of biochemical sensing platforms for personalized assessment of performance, wellness, and health across a broad range of applications.

Original language	English (US)
Pages (from-to)	2787-2801
Number of pages	15
Journal	ACS Sensors
Volume	6
Issue number	8
DOIs	https://doi.org/10.1021/acssensors.1c01133
State	Published - Aug 27 2021

Keywords

biosensors
eccrine sweat
epidermal microfluidics
flexible electronics
health monitoring
lab-on-chip
sweat analysis
wearable sensors

ASJC Scopus subject areas

Bioengineering
Instrumentation
Process Chemistry and Technology
Fluid Flow and Transfer Processes

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10.1021/acssensors.1c01133

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title = "State of Sweat: Emerging Wearable Systems for Real-Time, Noninvasive Sweat Sensing and Analytics",

abstract = "Skin-interfaced wearable systems with integrated colorimetric assays, microfluidic channels, and electrochemical sensors offer powerful capabilities for noninvasive, real-time sweat analysis. This Perspective details recent progress in the development and translation of novel wearable sensors for personalized assessment of sweat dynamics and biomarkers, with precise sampling and real-time analysis. Sensor accuracy, system ruggedness, and large-scale deployment in remote environments represent key opportunity areas, enabling broad deployment in the context of field studies, clinical trials, and recent commercialization. On-body measurements in these contexts show good agreement compared to conventional laboratory-based sweat analysis approaches. These device demonstrations highlight the utility of biochemical sensing platforms for personalized assessment of performance, wellness, and health across a broad range of applications.",

keywords = "biosensors, eccrine sweat, epidermal microfluidics, flexible electronics, health monitoring, lab-on-chip, sweat analysis, wearable sensors",

author = "Roozbeh Ghaffari and Yang, {Da Som} and Joohee Kim and Amer Mansour and Wright, {John A.} and Model, {Jeffrey B.} and Wright, {Donald E.} and Rogers, {John A.} and Ray, {Tyler R.}",

note = "Funding Information: We would like to acknowledge funding support provided by the Querrey Simpson Institute for Bioelectronics at Northwestern University. This publication was supported by the National Institute on Aging of the National Institutes of Health (R43AG067835). T.R.R. acknowledges additional support as a Junior Investigator from the National Institute of General Medical Sciences of the National Institutes of Health (P20GM113134) and the Hawai{\textquoteright}i Community Foundation (Robert C. Perry Fund). Publisher Copyright: {\textcopyright} 2021 American Chemical Society.",

year = "2021",

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doi = "10.1021/acssensors.1c01133",

language = "English (US)",

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AU - Ghaffari, Roozbeh

AU - Yang, Da Som

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AU - Mansour, Amer

AU - Wright, John A.

AU - Model, Jeffrey B.

AU - Wright, Donald E.

AU - Rogers, John A.

AU - Ray, Tyler R.

N1 - Funding Information: We would like to acknowledge funding support provided by the Querrey Simpson Institute for Bioelectronics at Northwestern University. This publication was supported by the National Institute on Aging of the National Institutes of Health (R43AG067835). T.R.R. acknowledges additional support as a Junior Investigator from the National Institute of General Medical Sciences of the National Institutes of Health (P20GM113134) and the Hawai’i Community Foundation (Robert C. Perry Fund). Publisher Copyright: © 2021 American Chemical Society.

PY - 2021/8/27

Y1 - 2021/8/27

N2 - Skin-interfaced wearable systems with integrated colorimetric assays, microfluidic channels, and electrochemical sensors offer powerful capabilities for noninvasive, real-time sweat analysis. This Perspective details recent progress in the development and translation of novel wearable sensors for personalized assessment of sweat dynamics and biomarkers, with precise sampling and real-time analysis. Sensor accuracy, system ruggedness, and large-scale deployment in remote environments represent key opportunity areas, enabling broad deployment in the context of field studies, clinical trials, and recent commercialization. On-body measurements in these contexts show good agreement compared to conventional laboratory-based sweat analysis approaches. These device demonstrations highlight the utility of biochemical sensing platforms for personalized assessment of performance, wellness, and health across a broad range of applications.

AB - Skin-interfaced wearable systems with integrated colorimetric assays, microfluidic channels, and electrochemical sensors offer powerful capabilities for noninvasive, real-time sweat analysis. This Perspective details recent progress in the development and translation of novel wearable sensors for personalized assessment of sweat dynamics and biomarkers, with precise sampling and real-time analysis. Sensor accuracy, system ruggedness, and large-scale deployment in remote environments represent key opportunity areas, enabling broad deployment in the context of field studies, clinical trials, and recent commercialization. On-body measurements in these contexts show good agreement compared to conventional laboratory-based sweat analysis approaches. These device demonstrations highlight the utility of biochemical sensing platforms for personalized assessment of performance, wellness, and health across a broad range of applications.

KW - biosensors

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State of Sweat: Emerging Wearable Systems for Real-Time, Noninvasive Sweat Sensing and Analytics

Abstract

Keywords

ASJC Scopus subject areas

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